One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women

Table 5 Effects of control and soy foods on on sex hormones

Measures	Control (n = 27)			Soy (n = 35)			Control vs Soy
	Baseline	6 months	Final	Baseline	6 months	Final	P values
							Trtmt	Time	Trtmt × Time
FSH (mIU/mL)	41.0 ± 3.8	37.5 ± 3.8	36.4 ± 3.8	44.8 ± 3.4	47.6 ± 3.4	43.2 ± 3.4	0.143	0.195	0.235
E₂ (pg/mL)	9.9 ± 4.1	12.3 ± 4.1	8.8 ± 4.2	12.7 ± 3.7	19.5 ± 3.7	17.7 ± 3.8	0.120	0.314	0.690
Estrone (pg/mL)	14.3 ± 4.3	21.9 ± 4.3	13.9 ± 4.4	19.6 ± 3.8	22.0 ± 3.9	22.4 ± 3.9	0.283	0.290	0.448
Estrone sulfate (ng/mL)	1.2 ± 0.4	1.9 ± 0.4	1.1 ± 0.4	1.8 ± 0.4	2.0 ± 0.4	1.9 ± 0.4	0.264	0.309	0.552
SHBG (nmol/L)	87.1 ± 9.2	81.3 ± 9.2	76.3 ± 9.3	105.3 ± 8.2	88.2 ± 8.2	90.0 ± 8.3	0.264	0.002	0.355

Values are least squares mean ± SE. FSH = follicle stimulating hormone; E₂ = 17β-estradiol; SHBG = sex hormone-binding globulin.
No treatment effects were detected.

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