|
Measures
|
Control (n = 27)
|
Soy (n = 35)
|
Control vs Soy
|
|---|
| |
Baseline
|
6 months
|
Final
|
Baseline
|
6 months
|
Final
|
P values
|
|---|
| | | | | | | |
Trtmt
|
Time
|
Trtmt × Time
|
|---|
|
Serum
| | | | | | | | | |
|---|
|
IGF-I (nmol/L)
|
17.9 ± 1.4b
|
20.5 ± 1.4a
|
20.2 ± 1.4a
|
13.3 ± 1.2c
|
16.8 ± 1.2ab
|
16.8 ± 1.2ab
|
0.023
|
< 0.001
|
0.693
|
|
IGFBP3 (ng/mL)
|
3833 ± 133
|
3934 ± 133
|
3904 ± 135
|
3442 ± 120b
|
3751 ± 120a
|
3622 ± 121a
|
0.087
|
0.005
|
0.252
|
|
Osteocalcin (ng/mL)
|
8.3 ± 2.1b
|
13.9 ± 2.1a
|
16.2 ± 2.2a
|
8.9 ± 1.9b
|
17.4 ± 2.0a
|
18.1 ± 2.0a
|
0.365
|
< 0.001
|
0.671
|
|
BSAP (U/L)
|
19.8 ± 1.2c
|
23.3 ± 1.2b
|
25.3 ± 1.2a
|
19.8 ± 1.1c
|
22.6 ± 1.1b
|
24.9 ± 1.1a
|
0.796
|
< 0.001
|
0.818
|
|
ALP (U/L)
|
57.4 ± 3.0c
|
65.9 ± 3.0b
|
74.0 ± 3.1a
|
56.6 ± 2.7c
|
69.1 ± 2.7b
|
74.3 ± 2.8a
|
0.798
|
< 0.001
|
0.499
|
|
Urine
| | | | | | | | | |
|
Dpd (nmol/mmol creatinine)
|
5.3 ± 0.4
|
5.3 ± 0.4
|
4.9 ± 0.4
|
5.2 ± 0.3
|
5.4 ± 0.3
|
5.1 ± 0.3
|
0.888
|
0.234
|
0.744
|
- Values are least squares mean ± SE. IGF-I = insulin-like growth factor-I; IGFBP-3 = insulin-like growth factor binding protein-3; BSAP = bone-specific alkaline phosphatase; ALP = alkaline phosphatase; Dpd = deoxypyridinoline.
- Within each row, values that do not share the same superscript letters are significantly (P < 0.05) different from each other.
