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Table 4 Effects of control and soy foods on serum and urinary markers of bone metabolism

From: One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women

Measures Control (n = 27) Soy (n = 35) Control vs Soy
  Baseline 6 months Final Baseline 6 months Final P values
        Trtmt Time Trtmt × Time
Serum          
IGF-I (nmol/L) 17.9 ± 1.4b 20.5 ± 1.4a 20.2 ± 1.4a 13.3 ± 1.2c 16.8 ± 1.2ab 16.8 ± 1.2ab 0.023 < 0.001 0.693
IGFBP3 (ng/mL) 3833 ± 133 3934 ± 133 3904 ± 135 3442 ± 120b 3751 ± 120a 3622 ± 121a 0.087 0.005 0.252
Osteocalcin (ng/mL) 8.3 ± 2.1b 13.9 ± 2.1a 16.2 ± 2.2a 8.9 ± 1.9b 17.4 ± 2.0a 18.1 ± 2.0a 0.365 < 0.001 0.671
BSAP (U/L) 19.8 ± 1.2c 23.3 ± 1.2b 25.3 ± 1.2a 19.8 ± 1.1c 22.6 ± 1.1b 24.9 ± 1.1a 0.796 < 0.001 0.818
ALP (U/L) 57.4 ± 3.0c 65.9 ± 3.0b 74.0 ± 3.1a 56.6 ± 2.7c 69.1 ± 2.7b 74.3 ± 2.8a 0.798 < 0.001 0.499
Urine          
Dpd (nmol/mmol creatinine) 5.3 ± 0.4 5.3 ± 0.4 4.9 ± 0.4 5.2 ± 0.3 5.4 ± 0.3 5.1 ± 0.3 0.888 0.234 0.744
  1. Values are least squares mean ± SE. IGF-I = insulin-like growth factor-I; IGFBP-3 = insulin-like growth factor binding protein-3; BSAP = bone-specific alkaline phosphatase; ALP = alkaline phosphatase; Dpd = deoxypyridinoline.
  2. Within each row, values that do not share the same superscript letters are significantly (P < 0.05) different from each other.