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Table 3 Effect of dietary Zn and Cu on plasma Cu concentration and Cp activity of rats

From: Copper Chaperone for Cu/Zn Superoxide Dismutase is a sensitive biomarker of mild copper deficiency induced by moderately high intakes of zinc

Animals Plasma Cu Concentration1,2 Cp Activity3,4
  Zn-30 Zn-60 Zn-120 Zn-240 Cu-D Zn-30 Zn-60 Zn-120 Zn-240 Cu-D
No. of non-responders 12 10 5 9 0 11 10 5 9 0
No. of responders5 0a 2ab 7b 3ab 12c 1a 2ab 7b 3ab 12c
Total 12 12 12 12 12 12 12 12 12 12
  1. 1 Non-responders had a range of 667.6 – 1291.6 μg/L.
  2. 2 Responders (range <0.1 – 572.4 μg/L) were those animals having plasma Cu concentration lower than 2SD below the mean plasma copper concentration of animals in the Zn-30 diet group (Zn-30; mean ± SD = 975.0 ± 159.4 μg/L).
  3. 3 Non-responders had a range of 65.3 – 152.8 U/L.
  4. 4 Responders (range <0.1 – 57.8 U/L) were those animals having Cp activity lower than 2SD below the mean Cp activity of animals in the Zn-30 diet group (Zn-30; mean ± SD = 106.5 ± 23.9).
  5. 5 No. of responders were compared using the Fisher exact test. For each diet group, No. of responders without a common letter differ, P < 0.05.