Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: The pleiotropic effects of folate supplementation

Table 1 Homocysteine lowering intervention trials for the prevention of CVD.

1. *SEARCH:*Study of the effectiveness of additional reduction in cholesterol and homocysteine. University of Oxford, England.
2. *PACIFIC:*Prevention with a combined inhibitor of folate in coronary heart disease. University of Sydney, Australia.
3. *WACS:*Women's antioxidant and cardiovascular disease study. Harvard Medical School, USA.
4. *CHAOS-2:*Cambridge heart antioxidant study. University of Cambridge, England.
5. *NORVITE:*Norwegian study of homocysteine lowering with B-vitamins in myocardial infarction. University of Tromso, Norway.
6. *BERGEN:*Bergen vitamin study. University of Bergen, Norway.
7. *HOPE-2:*Health outcome and prevention evaluation number 2. Canada.
8. *VISP*: Vitamin intervention for stroke prevention. Wake Forest University, USA.
9. *VITATOPS:*Vitamins to prevent strokes. Perth, Australia.
10. *IST-2:*International strokes trial number 2. Auckland, New Zealand.

ISSN: 1475-2891