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Table 1 Breast Cancer and Omega 3:6 Ratio.

From: Nutrition and cancer: A review of the evidence for an anti-cancer diet

Reference # of cases w/ breast cancer # of controls Post / pre Menopausal Measure of n-3 / n-6 fat Outcome Odds ratio (95% Confidence Interval)
[183] 565 554 (population and hospital) Pre & post Diet FFQ ↑N3/N6 ratio in premenopausal women = Non-signif. ↓Breast cancer risk 0.59 (0.29–1.19)
      In study site with population controls, find ↑N3/N6 ratio = Signif ↓Breast Cancer risk 0.50 (0.27, 0.95)
[184] EURAMIC study Nested case-control study in population study Post Adipose tissue 4 out of 5 centers showed ↑N3/N6 ratio = ↓Breast Cancer risk 0.65 (p for trend = 0.55)
[185] 241 88 w/ benign breast disease Both Adipose tissue ↑DHA = ↓Breast cancer 0.31 (0.13–0.75)
      ↑Ratio of long chain N-3:N-6 fat = ↓Breast cancer 0.33 (0.17–0.66)
[186] 73 74 w/ macromastia ? Adipose tissue N-6 fat content signif. higher in cases P = 0.02
      For given level of N-6 fat, EPA and DHA had a protective effect P = 0.06
[187] 71 (within ORDET study) 142 (nested case control) Post RBC membranes ↑DHA = ↓Breast cancer 0.44 (0.21–0.92)
[67] 380 397 Post Adipose tissue No associations between N-3:N-6 ratio and breast cancer  
[188] 314 (within Singapore Chinese Health study)    Diet, FFQ ↑Intake of N-3 fat from fish / shellfish = ↓Breast cancer, for all 3 highest quartiles 0.74 (0.58–0.94)
      Among women in lowest quartile of N-3 fat intake, ↑N-6 fat intake = ↓Breast cancer 1.87 (1.06–3.27)