TY - JOUR AU - Van Rosendaal, Guido MA AU - Shaffer, Eldon A. AU - Edwards, Alun L. AU - Brant, Rollin PY - 2004 DA - 2004/09/28 TI - Effect of time of administration on cholesterol-lowering by psyllium: a randomized cross-over study in normocholesterolemic or slightly hypercholesterolemic subjects JO - Nutrition Journal SP - 17 VL - 3 IS - 1 AB - Reports of the use of psyllium, largely in hypercholesterolemic men, have suggested that it lowers serum cholesterol as a result of the binding of bile acids in the intestinal lumen. Widespread advertisements have claimed an association between the use of soluble fibre from psyllium seed husk and a reduced risk of coronary heart disease. Given the purported mechanism of cholesterol-lowering by psyllium, we hypothesized that there would be a greater effect when psyllium is taken with breakfast than when taken at bedtime. Secondarily, we expected to confirm a cholesterol-lowering effect of psyllium in subjects with "average" cholesterol levels. SN - 1475-2891 UR - https://doi.org/10.1186/1475-2891-3-17 DO - 10.1186/1475-2891-3-17 ID - Van Rosendaal2004 ER -