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Table 5 Various inflammatory factors before and after operation between the two studied groups

From: Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients

 

Study group (N = 44)

control group (N = 41)

Difference 1,2 [95% C.I.]

P

IL-6 (pg/mL)

    

 Day -1

7.13 ± 19.22

21.16 ± 59.75

-13.724 [-32.496; 5.048]

0.150

 Before surgery

11.78 ± 21.30

26.01 ± 52.29

-13.793 [-30.417; 2.824]

0.103

 After surgery

126.56 ± 103.68

133.17 ± 109.18

-8.867 [-55.025; 37.291]

0.703

 Day 1

99.40 ± 88.12

99.88 ± 97.50

-0.958 [-41.005; 39.089]

0.962

 Day 3

35.72 ± 57.33

41.22 ± 63.48

-5.808 [-31.878; 20.262]

0.659

 Day 7

23.58 ± 45.25

26.44 ± 53.61

-2.741 [-24.202; 18.719]

0.800

 Follow up3

16.25 ± 19.46

22.15 ± 47.82

-5.810 [-21.446; 9.826]

0.462

 Day 7 – Day -1

16.45 ± 28.31

5.27 ± 53.00

6.648 [-10.876; 24.172]

0.453

CRP (mg/dL)

    

 Day -1

0.96 ± 1.80

2.04 ± 5.65

-1.069 [-2.857; 0.720]

0.238

 Before surgery

1.13 ± 1.79

1.75 ± 3.91

-0.615 [-1.919; 0.688]

0.350

 After surgery

1.52 ± 1.70

1.94 ± 3.49

-0.405 [-1.576; 0.765]

0.493

 Day 1

8.31 ± 4.68

9.17 ± 4.80

-0.837 [-2.877; 1.202]

0.416

 Day 3

10.20 ± 5.93

12.24 ± 7.52

-2.043 [-4.792; 0.885]

0.169

 Day 7

4.92 ± 4.60

4.95 ± 5.12

-0.040 [-2.152; 2.072]

0.970

 Follow up3

3.88 ± 4.72

5.23 ± 6.83

-1.304 [-3.804; 1.196]

0.303

 Day 7 – Day -1

3.95 ± 4.89

3.01 ± 7.11

-0.004 [-2.155; 2.148]

0.997

TNF-α (pg/mL)

    

 Day -1

2.00 ± 2.07

3.38 ± 6.59

-1.395 [-3.474; 0.685]

0.186

 Before surgery

2.01 ± 1.09

3.17 ± 6.71

-1.176 [-3.224; 0.872]

0.257

 After surgery

1.60 ± 1.43

3.05 ± 5.23

-1.475 [-3.096; 0.147]

0.074

 Day 1

1.72 ± 1.67

2.88 ± 4.01

-1.174 [-2.485; 0.137]

0.079

 Day 3

2.12 ± 2.24

3.33 ± 4.14

-1.237 [-2.653; 0.180]

0.086

 Day 7

2.55 ± 2.30

3.70 ± 5.83

-1.169 [-3.061; 0.724]

0.223

 Follow up3

2.42 ± 2.09

3.83 ± 5.44

-1.424 [-3.182; 0.334]

0.111

 Day 7 – Day -1

0.55 ± 1.38

0.38 ± 1.63

0.002 [-0.609; 0.612]

0.995

PCT (ng/mL)

    

 Day -1

0.06 ± 0.03

0.15 ± 0.37

-0.085 [-0.197; 0.027]

0.133

 Before surgery

0.13 ± 0.15

0.16 ± 0.25

-0.029 [-0.118; 0.060]

0.518

 After surgery

0.29 ± 0.31

0.32 ± 0.31

-0.029 [-0.163; 0.105]

0.671

 Day 1

0.65 ± 0.82

0.80 ± 1.29

-0.148 [-0.612; 0.316]

0.528

 Day 3

0.29 ± 0.29

0.41 ± 0.60

-0.125 [-0.325; 0.075]

0.216

 Day 7

0.14 ± 0.15

0.24 ± 0.48

-0.097 [-0.249; 0.056]

0.211

 Follow up3

0.12 ± 0.09

0.68 ± 1.88

-0.557 [-1.120; 0.006]

0.053

 Day 7 – Day -1

0.08 ± 0.15

0.09 ± 0.62

-0.101 [-0.256; 0.055]

0.202

  1. CRP: C-reactive protein; TNF-α: tumor necrosis factor-α; PCT: procalcitonin.
  2. 1Difference = [study group] - [control group].
  3. 2ANOVA incorporating center effect and their respective baseline as covariate; Difference and 95% C.I. was based on the LS-mean.
  4. 3Follow up was defined as 30 days after last treatment.