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Table 2 Comparison of baseline and day 7 biomarker values (N = 1615)

From: Effects of 7 days on an ad libitum low-fat vegan diet: the McDougall Program cohort

Variable Baseline, median (IQRa) Day 7, median (IQR) Change, median (IQRb) P-value
Weight, kg     
 Overall 84.4 (31.4) 82.6 (30.4) -1.4 (1.8) <.001
 Men 93.2 (32.2) 92.5 (30.8) -1.5 (2.2) <.001
 Women 79.2 (29.0) 78.0 (28.5) -1.4 (1.6) <.001
Total cholesterol, mg/dL     
 Overall 184 (56) 162 (49) -22 (29) <.001
  < 150 at baseline 133 (20) 126 (127) -8 (23) <.001
 150–179 at baseline 165 (16) 146 (25) -20 (24) <.001
 180–209 at baseline 193 (14) 169 (25) -25 (26) <.001
 210–239 at baseline 221 (15) 188 (28) -34 (27) <.001
  ≥ 240 at baseline 261 (31) 222 (43) -39 (29) <.001
HDL cholesterol, mg/dL (N = 1092) 49 (19) 40 (16) -8 (8) <.001
LDL cholesterol, mg/dL (N = 1091) 107 (49) 92 (41) -16 (23) <.001
Systolic blood pressure, mm Hg     
 Overall 128 (26) 120 (23) -8 (18) <.001
 Elevated (≥140) at baseline 150 (23) 136 (18) -18 (18) <.001
 Normal (<140) at baseline 120 (18.5) 114 (20) -4 (16) <.001
Diastolic blood pressure, mm Hg     
 Overall 80 (16) 74 (12) -4 (10) <.001
 Elevated (≥90) at baseline 94 (10) 83 (12) -11 (11) <.001
 Normal (<90) at baseline 76 (10) 70 (13) -3 (10) <.001
Triglycerides, mg/dL     
 Overall 118 (89) 118 (86) +2 (48) .344
 Normal (<150) 92 (49) 98 (53) +8 (34) <.001
 Borderline high (150–199) 169 (22) 157.5 (73.5) -11.5 (70.5) .004
 High (200–499) 247 (81) 216 (102) -46 (100) <.001
 Very high (≥500) 569 (109) 360 (98) -294 (131) <.001
Glucose, mg/dL     
 Overall 92 (19) 89 (15) -3 (11) <.001
  < 100 88 (9) 86 (9) -1 (7) <.001
 100 to 126 107 (10) 99 (13) -8 (18) <.001
  > 126 156 (72) 149 (84) -17 (45) <.001
Blood urea nitrogen, mg/dL     
 Overall 12 (5) 9 (4) -3 (4) <.001
  < 10 8 (2) 7 (3) -1 (2) <.001
 10 to 20 13 (4) 9 (3) -4 (3) <.001
  > 20 23 (6) 14 (7) -10 (5) <.001
Creatinine, mg/dL     
 Overall 0.8 (0.3) 0.8 (0.3) 0 (0.1) <.001
  < 1 0.8 (0.2) 0.8 (0.2) 0 (0.1) .100
 1 to 1.4 1.0 (0.2) 1.0 (0.1) 0 (0.1) <.001
  > 1.4 1.6 (0.3) 1.5 (0.3) 0.1 (0.2) .002
10-year risk for hard ASCVD,% (N = 1092) 4.0 (9.0) 3.9 (9.0) -1.0 (1.0) <.001
 Patients with elevated risk at baseline, percentage points (N = 403) 18.0 (17.5) 16.2 (16) -2.0 (4.1) <.001
  1. aIQR = interquartile range.
  2. bNotice that the change column is not the difference between the baseline and day 7 medians. The change score provided by the Wilcoxon signed rank test reflects the paired difference in the 2 scores.