Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose–response study

Table 2 Serum ucOC, Gla-OC, UGR, and dietary vitamin K intake values before and after MK-4 supplementation

Measurement day	Dosage	ucOC (ng/mL)		Gla-OC (ng/mL)		UGR		Dietary vitamin K intake (μg/week)
Measurement day	Dosage	Median	Range	Median	Range	Median	Range	Median	Range
Day 1	Baseline	5.03	(2.20-23.03)	18.41	(10.62-26.60)	0.32	(0.13-1.70)	-	-
Day 8	0 μg/day	5.81	(2.63-26.65)	18.71	(8.62-24.36)	0.36	(0.12-1.88)	40.18	(0.00-540.27)
Day 15	300 μg/day	6.77	(1.89-14.52)	21.27	(10.57-26.91)	0.35	(0.18-0.54)	17.40	(0.00-638.76)
Day 22	600 μg/day	4.82	(1.84-8.73)*	25.33	(12.29-33.04)	0.22	(0.14-0.31)**	31.68	(0.00-389.40)
Day 29	900 μg/day	2.98	(1.27-6.90)**	22.75	(12.38-38.10)*	0.15	(0.10-0.23)**	9.60	(0.00-196.94)
Day 36	1500 μg/day	3.92	(1.88-7.52)*	23.33	(13.97-45.49)**	0.15	(0.13-0.21)**	7.50	(0.00-167.58)

Data are shown as medians with ranges (minimum, maximum) (n = 13). Compared with baseline, serum ucOC levels and the UGR decreased significantly, whereas serum Gla-OC levels increased significantly. *P < 0.05, **P < 0.01 (Friedman’s test and the post hoc Bonferroni-adjusted Wilcoxon signed-rank test).

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