Test method | Test design | Substance | Subjects | Results | References |
---|---|---|---|---|---|
Oral consumption of HA at 240Â mg daily for 6Â weeks | Randomized, double-blind, placebo-controlled trial | HA (M.W.: 80Â K) | 22 patients with dry skin (in Japan) | Improved dry skin on the face and whole body | Kajimoto, O. et al. (2001) [15] |
Significant increase of skin moisture | |||||
Oral consumption of HA at 120Â mg daily for 4Â weeks | Randomized, double-blind, placebo-controlled trial | HA (M.W.: 80Â K) | 35 patients with dry skin (in Japan) | Significant increase of skin moisture | Sato, T. et al. (2002) [16] |
Oral consumption of HA at 120Â mg daily for 6Â weeks | Randomized, double-blind, placebo-controlled trial | HA (M.W.: 80Â K) | 39 female patients with dry skin (in Japan) | Significant increase of skin moisture | Sato, T. et al. (2007) [17] |
Oral consumption of HA at 120Â mg daily for 6Â weeks | Randomized, double-blind, placebo-controlled trial | HA (M.W.: 30Â K) | 42 female patients with dry skin (in Japan) | Significant increase of skin moisture | Yoshida, T. et al. (2009) [18] |
Oral consumption of HA at 37.52Â mg daily for 30Â days | Randomized, single-blind, placebo-controlled trial | Mixture containing HA (M.W. of HA: 2,500) | 107 healthy subjects (in China) | Significant increase in skin moisture | Terashita, T. et al. (2011) [19] |
Significant increase in skin pH | |||||
Oral consumption of HA at 100Â mg daily for 12Â weeks | Prospective open-label trial | Mixture containing HA(M.W.: unknown) | 26 healthy female subjects (Caucasian, African-American, Hispanic, and others) | Improved aging symptoms on the face | Schwartz, S. R. et al. (2012) [20] |