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Table 1 Summary on the skin improving effects of ingested hyaluronan

From: Ingested hyaluronan moisturizes dry skin

Test method

Test design

Substance

Subjects

Results

References

Oral consumption of HA at 240 mg daily for 6 weeks

Randomized, double-blind, placebo-controlled trial

HA (M.W.: 80 K)

22 patients with dry skin (in Japan)

Improved dry skin on the face and whole body

Kajimoto, O. et al. (2001) [15]

Significant increase of skin moisture

Oral consumption of HA at 120 mg daily for 4 weeks

Randomized, double-blind, placebo-controlled trial

HA (M.W.: 80 K)

35 patients with dry skin (in Japan)

Significant increase of skin moisture

Sato, T. et al. (2002) [16]

Oral consumption of HA at 120 mg daily for 6 weeks

Randomized, double-blind, placebo-controlled trial

HA (M.W.: 80 K)

39 female patients with dry skin (in Japan)

Significant increase of skin moisture

Sato, T. et al. (2007) [17]

Oral consumption of HA at 120 mg daily for 6 weeks

Randomized, double-blind, placebo-controlled trial

HA (M.W.: 30 K)

42 female patients with dry skin (in Japan)

Significant increase of skin moisture

Yoshida, T. et al. (2009) [18]

Oral consumption of HA at 37.52 mg daily for 30 days

Randomized, single-blind, placebo-controlled trial

Mixture containing HA (M.W. of HA: 2,500)

107 healthy subjects (in China)

Significant increase in skin moisture

Terashita, T. et al. (2011) [19]

Significant increase in skin pH

Oral consumption of HA at 100 mg daily for 12 weeks

Prospective open-label trial

Mixture containing HA(M.W.: unknown)

26 healthy female subjects (Caucasian, African-American, Hispanic, and others)

Improved aging symptoms on the face

Schwartz, S. R. et al. (2012) [20]