Skin moisture content changes by HA (MW: 8 × 10
) ingestion or placebo. 39 female subjects were randomly divided into two groups (HA group, n = 19; placebo group, n = 20) to minimize the inter-group differences in skin moisture content, skin elasticity and age. The skin moisture content at the lower part of the left eye was measured using a Corneometer® CM 825 before the control period, before the ingestion, and after 3 and 6 weeks of the ingestion. ■ indicates HA; □ indicates placebo. An unpaired t-test was used to compare the two groups. Data are presented as mean ± S.E. Asterisks indicate a statistically significant difference, *p < 0.05.