Effect of calcium phosphate and vitamin D3supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron

Table 4 Parameter of iron status after intervention with either tricalcium phosphate, vitamin D ₃ or both

Parameter	Supplements	Placebo	Interventions
Parameter	Supplements	Placebo	4 weeks	8 weeks
Plasma iron concentration [μmol/l]	CaP	18.8 (5.4)	18.3 (7.3)	19.5 (6.5)
	Vitamin D₃	22.3 (5.2)	20.8 (6.8)	20.5 (5.1)
	CaP+vitamin D₃	18.8 (6.7)	21.5 (5.2)	20.5 (5.5)
Plasma transferrin concentration [g/l]	CaP	2.5 (0.4)	2.4 (0.5)	2.5 (0.4)
	Vitamin D₃	2.7 (0.5)	2.6 (0.5)	2.6 (0.6)
	CaP+vitamin D₃	2.7 (0.4)	2.7 (0.4)	2.8 (0.6)
Transferrin saturation [%]	CaP	31.1 (10.1)	32.3 (16,8)	32.9 (10.9)
	Vitamin D₃	35.0 (11.2)	24.1 (14.4)	33.6 (9.2)
	CaP+vitamin D₃	29.1 (13.2)	32.0 (8.7)	31.3 (12.3)
Plasma ferritin [μg/l]	CaP	54.1 (28.4)¹	47.5 (21.7)¹	45.4 (22.6)
	Vitamin D₃	88.3 (65.1)¹²	81.0 (60.1)¹²	72.6 (43.4)
	CaP+vitamin D₃	134.6 (138.5)²	139.3 (151.3)²	105.0 (99.6)
Faecal iron excretion [mg/d]	CaP	8.7 (6.4)	7.7 (4.5)	7.7 (4.0)
	Vitamin D₃	9.1 (4.0)	9.5 (5.0)	8.3 (3.7)
	CaP+vitamin D₃	7.4 (2.9)	6.7 (2.4)	7.3 (2.9)

n = 51, except plasma transferrin n = 50; data are expressed as mean (standard deviation); CaP: tricalcium phosphate; ^{1 2} mean values within a column with dissimilar superscript numbers are significantly different (p ≤ 0.05); results without superscripts in a row/column have no significant differences; effect of time was tested using general linear model with repeated measurements (with pairwise comparisons based on Fishers-LSD test); effect of supplementation was tested using univariate analysis of variance followed by Student-Newman-Keuls post hoc test.

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