Table 4 Fasting glucose, fasting insulin, HOMA IR and matsuda index
Parameter | High dose OFS + P (N = 30) | Low dose OFS + P (N = 29) | Control (N = 29) |
|---|---|---|---|
Fasting glucose (mg/dl) | |||
Baseline mean (SD) | 93.8 (10.41) | 94.2 (8.55) | 90.3 (10.00) |
Week 3 mean (SD) | 90.9 (7.95) | 94.0 (7.71) | 91.5 (9.58) |
Week 3 LS mean change adjusted for baseline | −2.34 | 0.57 | −0.06 |
LS Mean difference from control (95% CI) | −2.28 (−6.03, 1.46) | 0.63 (−3.15, 4.42) | |
Fasting insulin (pmol/L) | |||
Baseline geometric mean (SD log-scale) | 37.5 (0.59) | 40.6 (0.56) | 40.4 (0.49) |
Week 3 geometric mean (SD log-scale) | 34.0 (0.52) | 37.8 (0.54) | 42.8 (0.61) |
Week 3 geometric LS mean adjusted for baseline (SE log-scale) | 35.4 (0.07) | 37.0 (0.07) | 42.0 (0.07) |
Geometric LS mean ratio relative to control (95% CI) | 0.84 (0.70, 1.01) | 0.88 (0.73, 0.1.06) | |
Matsuda index | |||
Baseline geometric mean (SD log-scale) | 11.5 (0.56) | 9.9 (0.55) | 10.4 (0.52) |
Week 3 geometric mean (SD log-scale) | 11.7 (0.49) | 10.2 (0.53) | 8.8 (0.60) |
Week 3 geometric LS mean adjusted for baseline (SE log-scale) | 10.9 (0.06) | 10.8 (0.06) | 9.0 (0.06) |
Geometric LS mean ratio relative to control (95% CI) | 1.22 (1.04, 1.43) | 1.21 (1.03, 1.42) | |
(N = 25) | (N = 25) | (N = 26) | |
HOMA-IR | |||
Baseline geometric mean (SD log-scale) | 0.79 (0.506) | 0.87 (0.422) | 0.79 (0.447) |
Week 3 geometric mean (SD log-scale) | 0.71 (0.404) | 0.78 (0.452) | 0.91 (0.507) |
Week 3 geometric LS mean adjusted for baseline (SE log-scale) | 0.75 (0.067) | 0.78 (0.067) | 0.92 (0.066) |
Geometric LS mean ratio relative to control (95% CI) | 0.82 (0.68, 0.98) | 0.85 (0.70, 1.02) | |