Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts

Table 2 Annual change in body weight (kg) and waist circumference (cm) pr. 100 mg/day higher ascorbic acid intake in the three cohorts

	N	Crude β (95% CI)¹	% weight³	Adjusted β (95% CI)²	% weight
Annual weight change (kg)
MONICA	1,329	−0.024 (−0.097 to 0.049)	36.38	−0.018 (−0.093 to 0.057)	36.84
DCH	2,167	−0.103 (−0.192 to −0.015)	24.71	−0.082 (−0.172 to 0.009)	25.11
INTER99	4,073	−0.035 (−0.106 to 0.035)	38.91	0.035 (−0.039 to 0.108)	38.05
Overall	7,569	−0.048 (−0.092 to −0.004)	100	−0.014 (−0.059 to 0.031)	100
Annual waist change (cm)
DCH	2,128	−0.119 (−0.246 to 0.007)	32.82	−0.111 (−0.219 to 0.003)	26.28
INTER99	3,536	−0.010 (−0.098 to 0.079)	67.12	0.010 (−0.074 to 0.055)	73.72
Overall	5,664	−0.046 (−0.118 to 0.027)	100	−0.034 (−0.089 to 0.021)	100

¹Adjusted for baseline outcome and height.
²Adjusted for baseline outcome, height, sex, age, smoking status, alcohol consumption, physical activity, education and menopausal status for women. Analysis with change in waist circumference adjusted for concurrent weight change.
³Estimates were calculated in MONICA, DCH and INTER99 using linear regression and meta-analysed using a fixed effect meta-analysis approach. Individual cohorts were weighted based on the inverses of their variances (% weight).

ISSN: 1475-2891