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Table 4 Multiple regressions to assess independent relationships between apolipoprotein A-V and clinical variables

From: Effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein A-V levels in patients with impaired fasting glucose or new-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism

Variable

Changed apo A-V levels

Total subjects

TT allele

C allele (TC and CC)

Regression coefficients

P-value

Regression coefficients

P-value

Regression coefficients

P-value

[95% CI†]

[95% CI†]

[95% CI†]

APOA5 -1131 T > C genotype

−24.532 [−47.596, −1.469]

0.037

-

-

-

-

Age

0.427 [−0.839, 1.693]

0.507

0.477 [−1.512, 2.465]

0.634

−0.204 [−1.880, 1.471]

0.809

Baseline levels

      

  Body mass index

1.078 [−3.811, 5.966]

0.664

0.812 [−6.501, 8.124]

0.826

2.696 [−4.004, 9.396]

0.426

  Apo A-V∮

−107.870 [−132.432, −83.308]

<0.001

−112.767 [−151.730, −73.804]

<0.001

−101.958 [−133.939, −69.976]

<0.001

  Triglycerides∮

−17.959 [−43.321, 7.402]

0.164

−19.362 [−61.602, 22.877]

0.364

−14.284 [−48.109, 19.542]

0.404

  HDL cholesterol∮

24.125 [−31.326, 79.576]

0.392

−2.779 [−88.093, 82.536]

0.948

49.796 [−27.506, 127.097]

0.204

  Glucose∮

−33.234 [−182.983, 116.516]

0.662

−210.610 [−463.912, 42.691]

0.102

129.957 [−64.812, 324.727]

0.188

  HOMA-IR∮

22.975 [−12.858, 58.809]

0.207

12.221 [−49.304, 73.746]

0.693

14.817 [−30.146, 59.781]

0.514

  Free fatty acids∮

26.503 [−4.251, 57.257]

0.551

42.963 [−5.154, 91.081]

0.079

9.158 [−32.164, 50.480]

0.661

Changed levels

      

  Triglycerides∮

0.066 [−0.152, 0.284]

0.551

−0.404 [−0.784, −0.024]

0.038

0.349 [0.085, 0.612]

0.010

  HDL cholesterol∮

2.550 [1.455, 3.645]

<0.001

3.280 [1.274, 5.287]

0.002

2.239 [0.915, 3.563]

0.001

  Glucose∮

−0.121 [−1.018, 0.775]

0.790

−0.631 [−2.905, 1.643]

0.582

−0.363 [−1.397, 0.671]

0.487

  HOMA-IR∮

−4.036 [−17.793, 9.721]

0.563

0.119 [−22.914, 23.152]

0.992

−8.468 [−25.418, 8.481]

0.324

  Free fatty acids∮

0.085 [0.034, 0.135]

0.001

0.079 [−0.005, 0.164]

0.065

0.071 [0.006, 0.137]

0.034

 

R 2 = 0.459, adjusted R 2 = 0.416

R 2 = 0.524, adjusted R 2 = 0.440

R 2 = 0.525, adjusted R 2 = 0.455

 

P < 0.001

P < 0.001

P < 0.001

  1. ∮Log-transformed. †Confidence interval.
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Nutrition Journal

ISSN: 1475-2891

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