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Table 4 Multiple regressions to assess independent relationships between apolipoprotein A-V and clinical variables

From: Effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein A-V levels in patients with impaired fasting glucose or new-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism

Variable Changed apo A-V levels
Total subjects TT allele C allele (TC and CC)
Regression coefficients P-value Regression coefficients P-value Regression coefficients P-value
[95% CI] [95% CI] [95% CI]
APOA5 -1131 T > C genotype −24.532 [−47.596, −1.469] 0.037 - - - -
Age 0.427 [−0.839, 1.693] 0.507 0.477 [−1.512, 2.465] 0.634 −0.204 [−1.880, 1.471] 0.809
Baseline levels       
  Body mass index 1.078 [−3.811, 5.966] 0.664 0.812 [−6.501, 8.124] 0.826 2.696 [−4.004, 9.396] 0.426
  Apo A-V −107.870 [−132.432, −83.308] <0.001 −112.767 [−151.730, −73.804] <0.001 −101.958 [−133.939, −69.976] <0.001
  Triglycerides −17.959 [−43.321, 7.402] 0.164 −19.362 [−61.602, 22.877] 0.364 −14.284 [−48.109, 19.542] 0.404
  HDL cholesterol 24.125 [−31.326, 79.576] 0.392 −2.779 [−88.093, 82.536] 0.948 49.796 [−27.506, 127.097] 0.204
  Glucose −33.234 [−182.983, 116.516] 0.662 −210.610 [−463.912, 42.691] 0.102 129.957 [−64.812, 324.727] 0.188
  HOMA-IR 22.975 [−12.858, 58.809] 0.207 12.221 [−49.304, 73.746] 0.693 14.817 [−30.146, 59.781] 0.514
  Free fatty acids 26.503 [−4.251, 57.257] 0.551 42.963 [−5.154, 91.081] 0.079 9.158 [−32.164, 50.480] 0.661
Changed levels       
  Triglycerides 0.066 [−0.152, 0.284] 0.551 −0.404 [−0.784, −0.024] 0.038 0.349 [0.085, 0.612] 0.010
  HDL cholesterol 2.550 [1.455, 3.645] <0.001 3.280 [1.274, 5.287] 0.002 2.239 [0.915, 3.563] 0.001
  Glucose −0.121 [−1.018, 0.775] 0.790 −0.631 [−2.905, 1.643] 0.582 −0.363 [−1.397, 0.671] 0.487
  HOMA-IR −4.036 [−17.793, 9.721] 0.563 0.119 [−22.914, 23.152] 0.992 −8.468 [−25.418, 8.481] 0.324
  Free fatty acids 0.085 [0.034, 0.135] 0.001 0.079 [−0.005, 0.164] 0.065 0.071 [0.006, 0.137] 0.034
  R 2 = 0.459, adjusted R 2 = 0.416 R 2 = 0.524, adjusted R 2 = 0.440 R 2 = 0.525, adjusted R 2 = 0.455
  P < 0.001 P < 0.001 P < 0.001
  1. Log-transformed. Confidence interval.