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Table 2 Effects of a 3-year dietary intervention on apolipoprotein A-V, triglycerides, HDL, glucose, insulin, HOMA-IR, LDL particle size, MDA, and ba-PWV at baseline and the 3-year follow-up visit as a function of the APOA5 -1131 T > C genotype

From: Effects of a 3-year dietary intervention on age-related changes in triglyceride and apolipoprotein A-V levels in patients with impaired fasting glucose or new-onset type 2 diabetes as a function of the APOA5 -1131 T > C polymorphism

  APOA5-1131 T > C P-value P a-value
  TT (n = 91) TC and CC (n = 112)
Apolipoprotein A-V (ng/mL)     
  Before 217.8±10.6 188.6±10.2 0.011  
  After 210.0±10.8 166.4±8.32* 0.001  
  Change −7.77±10.8 −23.0±9.35 0.285 0.004
Triglycerides (mg/dL)     
  Before 110.9±6.20 132.5±7.28 0.022  
  After 103.0±6.88* 147.6±8.51 <0.001  
  Change −7.88±5.44 15.0±5.88 0.005 0.001
HDL cholesterol (mg/dL)     
  Before 55.1±1.53 50.8±1.26 0.024  
  After 53.5±1.46 47.7±1.39** 0.001  
  Change −1.62±1.15 −3.11±1.18 0.372 0.051
Glucose (mg/dL)     
  Before 109.7±1.00 109.9±0.90 0.874  
  After 105.7±1.10*** 110.4±2.11 0.064  
  Change −4.07±0.98 0.46±1.68 0.030 0.030
Insulin (μIU/mL)     
  Before 9.19±0.36 8.93±0.37 0.425  
  After 7.96±0.36*** 8.52±0.39 0.375  
  Change −1.23±0.38 −0.41±0.35 0.115 0.173
1HOMA-IR     
  Before 2.51±0.11 2.44±0.11 0.469  
  After 2.10±0.10*** 2.36±0.13 0.177  
  Change −0.39±0.11 −0.07±0.10 0.034 0.047
Free fatty acids (μEq/L)     
  Before 540.8±22.8 523.7±20.3 0.577  
  After 494.2±24.1* 502.4±22.0 0.836  
  Change −46.6±25.6 −21.3±24.9 0.481 0.620
LDL particle size (nm)     
  Before 23.7±0.10 23.7±0.08 0.648  
  After 23.8±0.11 23.4±0.09* 0.008  
  Change 0.10±0.09 −0.23±0.09 0.014 0.006
2MDA (nmol/mL)     
  Before 10.1±0.31 10.5±0.29 0.418  
  After 10.7±0.42 11.9±0.35*** 0.020  
  Change 0.48±0.39 1.38±0.32 0.078 0.048
3ba-PWV (cm/sec)     
  Before 2678.0±36.4 2707.3±42.9 0.736  
  After 2701.4±38.9 2804.6±46.4*** 0.134  
  Change 23.4±29.7 97.3±25.3 0.058 0.046
  1. Mean ± S.E.Log-transformed, * P < 0.05, ** P < 0.01, *** P < 0.001 compared with baseline values for each genotype tested by paired t-test. P-values derived from independent t-test. P a-values derived from independent t-test after adjusting for baseline values. 1HOMA-IR = {fasting insulin (μIU/mL) × fasting glucose (mmol/L)}/22.5. 2MDA = malondialdehyde. 3ba-PWV = brachial-ankle pulse wave velocity.