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Table 1 In vivo studies performed with the proprietary yeast β-glucan preparation Yestimun ®

From: Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan

Title/reference Study design/duration/dosage Main results
Effect of β-1,3/1,6-D-glucan on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats [34] 20 adult rats were fed for 14 days with either 12–19 mg/rat/day β-1,3/1,6-D-glucan (Biolex-Beta HP*) or control diet Arterial blood was analyzed for phagocytic activity and oxidative metabolism in blood granulocytes and monocytes:
• significant higher phagocytic activity and a significant higher percentage of phagocytic cells in granulocytes and monocytes of β-glucan fed animal
• positive effects on the oxidative metabolism of these cell types
• monocytes stimulated by E. coli showed significantly higher oxidative metabolism in the β-glucan group
Effect of Biolex β-HP on selected parameters of specific and non-specific humoral and cellular immunity in rats [28] 20 adult rats were fed for 14 days with either 12–19 mg/rat/day β-1,3/1,6-D-glucan (Biolex-Beta HP*) or control diet Orally applied insoluble β-glucans are able to increase non-specific humoral immune parameters in rats:
• lysozyme and ceruloplasmin activities and serum gamma-globulin levels were significant higher
• significant higher respiratory burst activity and potential killing activity of blood phagocytic cells
• significant higher proliferation rate of blood lymphocytes when stimulated by ConA or LPS
Effect of Biolex Beta-HP on phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats intoxicated by cyclophosphamide [27] 10 adult rats (control) and 10 rats treated with cyclophosphamide were fed for 14 days with β-(1,3)-(1,6)-D-glucan (Biolex-Beta HP*) at a dose of 50 mg/kg body weight/day or control diet Under the condition of an experimentally suppressed immune system (treatment with cyclophosphamide), feeding with β-glucan led to:
• increase of percentage of phagocytic monocytes and granulocytes
• improvement of phagocytic activity of monocytes and granulocytes
• a high level of oxidative metabolism of granulocytes and monocytes stimulated with fMLP, PMA and E. coli
The effectiveness of natural and synthetic immunomodulators in the treatment of inflammatory bowel disease in dogs [35] 28 dogs with IBD were treated for 42 days with Feeding with β-glucan led to:
I) β-(1,3)-(1,6)-D-glucan (Biolex-Beta HP*) at a dose of 7 mg/kg body weight/day • decrease of the IBD symptoms measured by IBD Activity Index
II) β-hydroxy- β-metyl butyrate 30 mg/kg bw/day • decrease of the pro-inflammatory interleukin IL-6
III) levamisol 2 mg/kg bw/day • increase of the anti-inflammatory interleukin IL-10
  IV) control, without supplementation  
  1. *Yestimun® was previously called Biolex-Beta HP.