Table 1 In vivo studies performed with the proprietary yeast β-glucan preparation Yestimun ®
From: Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan
Title/reference | Study design/duration/dosage | Main results |
|---|---|---|
Effect of β-1,3/1,6-D-glucan on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats [34] | 20 adult rats were fed for 14 days with either 12–19 mg/rat/day β-1,3/1,6-D-glucan (Biolex-Beta HP*) or control diet | Arterial blood was analyzed for phagocytic activity and oxidative metabolism in blood granulocytes and monocytes: |
• significant higher phagocytic activity and a significant higher percentage of phagocytic cells in granulocytes and monocytes of β-glucan fed animal | ||
• positive effects on the oxidative metabolism of these cell types | ||
• monocytes stimulated by E. coli showed significantly higher oxidative metabolism in the β-glucan group | ||
Effect of Biolex β-HP on selected parameters of specific and non-specific humoral and cellular immunity in rats [28] | 20 adult rats were fed for 14 days with either 12–19 mg/rat/day β-1,3/1,6-D-glucan (Biolex-Beta HP*) or control diet | Orally applied insoluble β-glucans are able to increase non-specific humoral immune parameters in rats: |
• lysozyme and ceruloplasmin activities and serum gamma-globulin levels were significant higher | ||
• significant higher respiratory burst activity and potential killing activity of blood phagocytic cells | ||
• significant higher proliferation rate of blood lymphocytes when stimulated by ConA or LPS | ||
Effect of Biolex Beta-HP on phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats intoxicated by cyclophosphamide [27] | 10 adult rats (control) and 10 rats treated with cyclophosphamide were fed for 14 days with β-(1,3)-(1,6)-D-glucan (Biolex-Beta HP*) at a dose of 50 mg/kg body weight/day or control diet | Under the condition of an experimentally suppressed immune system (treatment with cyclophosphamide), feeding with β-glucan led to: |
• increase of percentage of phagocytic monocytes and granulocytes | ||
• improvement of phagocytic activity of monocytes and granulocytes | ||
• a high level of oxidative metabolism of granulocytes and monocytes stimulated with fMLP, PMA and E. coli | ||
The effectiveness of natural and synthetic immunomodulators in the treatment of inflammatory bowel disease in dogs [35] | 28 dogs with IBD were treated for 42 days with | Feeding with β-glucan led to: |
I) β-(1,3)-(1,6)-D-glucan (Biolex-Beta HP*) at a dose of 7 mg/kg body weight/day | • decrease of the IBD symptoms measured by IBD Activity Index | |
II) β-hydroxy- β-metyl butyrate 30 mg/kg bw/day | • decrease of the pro-inflammatory interleukin IL-6 | |
III) levamisol 2 mg/kg bw/day | • increase of the anti-inflammatory interleukin IL-10 | |
IV) control, without supplementation |