Table 5 Safety assessments in participants taking either rice bran fermented with Lentinus edodes (RBEP) or placebo 1
RBEP (n = 40) | Placebo (n = 37) | |||||
|---|---|---|---|---|---|---|
Week 0 | Week 4 | Week 8 | Week 0 | Week 4 | Week 8 | |
Red blood cell count (× 1012/L) | 4.33 ± 0.43 | 4.47 ± 0.50 | 4.47 ± 0.44 | 4.38 ± 0.43 | 4.58 ± 0.41 | 4.56 ± 0.42 |
White blood cell count (× 109/L) | 5.96 ± 1.14 | 5.82 ± 1.21 | 5.52 ± 1.12 | 5.85 ± 1.40 | 5.79 ± 1.16 | 5.85 ± 1.20 |
Hemoglobin (g/L) | 140.10 ± 13.10 | 138.70 ± 14.00 | 139.60 ± 13.30 | 140.10 ± 12.60 | 140.50 ± 12.00 | 140.30 ± 12.70 |
Hematocrit (%) | 41.45 ± 4.13 | 42.38 ± 4.48 | 42.09 ± 3.85 | 41.46 ± 3.90 | 42.76 ± 3.62 | 42.34 ± 3.99 |
Platelet count (× 109/L) | 236.13 ± 39.602 | 242.18 ± 46.44 | 243.35 ± 45.91 | 259.11 ± 61.152 | 266.19 ± 55.50 | 267.97 ± 46.08 |
Segmented neutrophils (%) | 54.75 ± 7.61 | 53.25 ± 5.79 | 53.30 ± 7.13 | 54.65 ± 8.47 | 54.91 ± 5.77 | 54.97 ± 5.95 |
Lymphocytes (%) | 34.83 ± 7.29 | 37.60 ± 5.95 | 36.80 ± 6.65 | 36.27 ± 7.25 | 35.78 ± 5.80 | 35.05 ± 5.52 |
Monocytes (%) | 6.63 ± 1.51 | 5.90 ± 1.22 | 6.53 ± 1.45 | 6.19 ± 1.29 | 5.84 ± 1.48 | 6.30 ± 1.61 |
Eosinophils (%) | 2.78 ± 1.21 | 2.38 ± 0.90 | 2.38 ± 1.17 | 2.51 ± 1.26 | 2.32 ± 1.08 | 2.73 ± 1.35 |
Basophils (%) | 1.03 ± 0.48 | 0.88 ± 0.52 | 1.00 ± 0.55 | 0.84 ± 0.55 | 0.97 ± 0.44 | 0.95 ± 0.57 |
AST (U/I) | 21.25 ± 6.41 | 21.88 ± 7.77 | 23.58 ± 9.67 | 25.24 ± 11.25 | 24.16 ± 7.30 | 25.65 ± 10.63 |
ALT (U/I) | 17.20 ± 14.66 | 17.50 ± 22.40 | 25.53 ± 27.40 | 22.51 ± 16.31 | 21.24 ± 13.41 | 27.57 ± 19.08 |
Total protein (g/L) | 72.20 ± 4.00 | 72.60 ± 5.00 | 73.50 ± 3.90 | 73.20 ± 3.80 | 72.50 ± 5.30 | 74.20 ± 3.70 |
Glucose (mmol/L) | 4.43 ± 0.37 | 4.31 ± 0.30 | 4.86 ± 0.45 | 4.55 ± 0.37 | 4.44 ± 0.31 | 4.97 ± 0.38 |
Total cholesterol (mmol/L) | 4.74 ± 0.81 | 4.64 ± 0.81 | 5.00 ± 0.84 | 4.87 ± 0.90 | 4.81 ± 0.90 | 5.22 ± 0.88 |
Blood urea nitrogen (mmol/L) | 4.33 ± 0.81 | 4.51 ± 1.16 | 4.84 ± 1.12 | 4.45 ± 1.07 | 4.59 ± 1.21 | 5.03 ± 1.10 |
Creatinine (μmol/L) | 60.25 ± 10.68 | 68.63 ± 15.25 | 61.01 ± 10.68 | 61.77 ± 14.49 | 67.11 ± 14.21 | 62.53 ± 14.00 |
Uric acid (μmol/L) | 294.43 ± 63.642 | 281.34 ± 55.91 | 311.08 ± 73.16 | 318.81 ± 74.35 | 293.24 ± 60.07 | 342.60 ± 77.32 |
Calcium (mmol/L) | 2.24 ± 0.08 | 2.27 ± 0.06 | 2.25 ± 0.06 | 2.23 ± 0.08 | 2.26 ± 0.07 | 2.24 ± 0.06 |
Phosphorus (mmol/L) | 1.14 ± 0.14 | 1.24 ± 0.10 | 1.22 ± 0.09 | 1.15 ± 0.12 | 1.21 ± 0.12 | 1.22 ± 0.11 |
SBP (mmHg) | 116.43 ± 15.20 | 116.03 ± 11.76 | 120.15 ± 13.55 | 118.87 ± 11.73 | 117.46 ± 12.05 | 121.32 ± 13.54 |
DBP (mmHg) | 71.73 ± 9.73 | 71.98 ± 9.74 | 74.85 ± 9.73 | 71.11 ± 8.97 | 73.65 ± 9.39 | 75.59 ± 10.39 |
Pulse rate (beats/min) | 76.48 ± 9.93 | 75.53 ± 10.89 | 75.50 ± 10.61 | 73.22 ± 11.01 | 75.54 ± 10.81 | 74.68 ± 10.24 |
Body temperature (°C) | 36.24 ± 0.38 | 35.95 ± 0.35 | 35.97 ± 0.44 | 36.29 ± 0.41 | 36.15 ± 0.44 | 36.04 ± 0.42 |