Mean responses to the MedDiet in groups of HDL-C “responders” and “non-responders”. Panel A Individual HDL-C responses to the MedDiet vs. control diet among the 26 men with MetS. Responders and non-responders of HDL-C were defined based on the change in plasma HDL-C concentrations being positive (≥0.05 mmol/L) or negative (≤0.05 mmol/L). Panel B Percent change from the control diet in metabolic variables according to changes in HDL-C with MedDiet (responders vs. non-responders). The P value for comparison between responders and non-responders is based on the Wilcoxon-Mann–Whitney test; P values for the change vs. control diet within groups is based on pair signed ranks test. Significant within-diet change from the control diet, *P < 0.05, †P < 0.11.