Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study

Table 3 Polyunsaturated fatty acids profile in plasma

Parameter (μg FA/ml)	Baseline mean (SD)	Change at week 8	95% CI	P-value	Change at week 16	95% CI	P-value
ALA	13.50 (8.50)	-2.08	-4.71 to 0.56	0.1194	-3.71	-6.35 to -1.08	0.0067
EPA	8.73 (4.09)	17.96	12.42 to 23.50	<0.0001	10.47	4.93 to 16.00	0.0004
DPA	8.24 (2.88)	3.63	2.10 to 5.16	<0.0001	0.56	-0.97 to 2.09	0.4665
DHA	32.91 (8.24)	18.39	12.05 to 24.73	<0.0001	9.93	3.60 to 16.27	0.0028
EPA+DHA	41.63 (10.68)	36.35	25.16 to 47.55	<0.0001	20.40	9.21 to 31.6	0.0006
LA	624.25 (137.45)	7.30	-52.75 to 67.34	0.8081	-55.81	-115.86 to 4.24	0.0678
GLA	10.01 (4.40)	0.75	-1.83 to 3.32	0.5615	-1.55	-4.12 to 1.03	0.2330
DGLA	35.07 (13.03)	-3.32	-7.89 to 1.25	0.1550	-7.50	-12.07 to -2.93	0.0018
AA	148.24 (38.47)	-11.57	-27.37 to 4.24	0.1477	-26.56	-42.37 to -10.76	0.0015

Data are presented as mean (standard deviation);
FA- fatty acid; ALA – α-linolenic acid, 18:3 (n-3); EPA – eicosapentaenoic acid, 20:5 (n-3); DPA – docosapentaenoic acid, 22:5 (n-3); DHA – docosahexaenoic acid, 22:6 (n-3); LA – linoleic acid, 18:2 (n-6); GLA – γ-linolenic acid, 18:3 (n-6); DGLA – dihomo-γ-linolenic acid, 20:3 (n-6); AA – arachidonic acid, 20:4 (n-6); P-value derived with mixed model.