High solubility | Low solubility | |
---|---|---|
High permeability | Class I | Class II |
High solubility | Low solubility | |
High permeability | High permeability | |
Transporter effects minimal | Efflux (flows out) transporter effects predominate | |
Examples: Atropine, Caffeine, Diazepam, Glucose, Levodopa, Prednisolone | Examples: Digoxin, Ibuprofen, Warfarin | |
Low permeability | Class III | Class IV |
High solubility | Low solubility | |
Low permeability | Low permeability | |
Absorptive transporter effects predominate | Absorptive and efflux transporter effects could be important | |
Examples: Atenolol, Captopril, Cimetidine, Acyclovir, Penicillin, Amoxicillin, Erythromycin | Examples: Amphotericin B, Chlothalidone, Neomycin |