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Table 6 Pregnancy outcomes and neonatal anthropometry, overall and by study group

From: Randomized placebo-controlled trial of high-dose prenatal third-trimester vitamin D3 supplementation in Bangladesh: the AViDD trial

Outcome

Overall

Placebo

Vitamin D

p 2

(n = 147)

(n = 74)

(n = 73)

Location of delivery 1

    

   Shimantik Maternity centre

124 (84.4)

62 (83.8)

62 (84.9)

1.00

   Home

13 (8.8)

7 (9.7)

6 (8.2)

 

   Other hospital or clinic

1 (0.7)

0 (0)

1 (1.4)

 

   Other

9 (6.1)

5 (6.8)

4 (5.5)

 

Mode of delivery

    

   Vaginal

59 (40.1)

30 (40.5)

29 (39.7)

1.00

   C-section

88 (59.7)

44 (59.7)

44 (60.3)

 

Vaginal delivery 3

    

   Spontaneous

54 (91.5)

28 (93.3)

26 (89.7)

0.80

   Forceps

3 (5.1)

1 (3.3)

2 (6.9)

 

   Unknown

2 (3.4)

1 (3.3)

1 (3.5)

 

Indication for c-section 4

    

   Urgent

76 (81.7)

41 (89.1)

35 (74.5)

0.17

   Elective

11 (11.8)

3 (6.5)

8 (17.0)

 

   Unknown

6 (6.5)

2 (4.4)

4 (8.5)

 

Maternal serious clinical adverse events 5

4 (2.5)

2 (2.7)

2 (2.7)

1.00

Gestational age at birth, wks 6

38.4 ± 2.1

38.5 ± 2.1

38.2 ± 2.1

0.31

Infant anthropometry

    

   Birth weight, g7

2795 ± 467

2788 ± 378

2802 ± 543

0.86

   Length at birth, cm8

48.1 ± 2.5

48.0 ± 2.0

48.2 ± 2.5

0.55

   Head circumference, cm9

33.0 ± 1.7

33.0 ± 1.5

32.9 ± 1.8

0.71

Total births registered 10

147 (91.9)

74 (92.5)

73 (91.3)

0.77

   Live births11

145 (98.6)

73 (98.6)

72 (98.6)

0.99

   Stillbirths11

2 (1.4)

1 (1.4)

1 (1.4)

1.00

Neonatal clinical adverse events

    

   Neonatal serious non-fatal adverse events

13 (8.8)

7 (9.5)

6 (8.2)

0.81

   Neonatal deaths

4 (2.8)

3 (4.1)

1 (1.4)

0.62

  1. 1 n (%).
  2. 2 p-value for Student’s t-test for means and Fischer’s exact test for proportions, conducted for variables with cell counts <5.
  3. 3 n = 59, as mode of delivery was vaginal.
  4. 4 n = 88, as mode of delivery was c-section.
  5. 5 Maternal serious adverse events included gastroenteritis, preterm delivery with premature rupture of membranes, injury (15% flame burn), and pre-eclampsia.
  6. 6 Mean ± standard deviation (SD).
  7. 7 Birth weight was missing for 2 infants in the placebo group and 1 in the vitamin D group.
  8. 8 n = 137 (69 in placebo, 68 in the vitamin D group).
  9. 9 n = 132 (65 in placebo, 67 in vitamin D group).
  10. 10 Denominator for calculation of proportions was the total number of women enrolled (n = 160).
  11. 11 Denominator for calculation of proportions was the total number of births registered (n = 147).