Blood pressure and endothelial function in healthy, pregnant women after acute and daily consumption of flavanol-rich chocolate: a pilot, randomized controlled trial

Table 6 Chronic changes in methylxanthine concentrations after daily consumption of 20-g chocolate

	Low-flavanol	High-flavanol	Pvalue of change between treatments
	Chocolate	Chocolate
	(n = 20)	(n = 22)
Theobromine (μg/mL)
Baseline	0.35 ± 0.37	0.45 ± 0.43	-
Week 6	1.44 ± 0.73	1.82 ± 0.76	0.34
Week 12	1.30 ± 0.69	1.87 ± 0.85	0.03
P value (Week 6 vs. Baseline)	<0.0001	<0.0001
P value (Week 12 vs. Baseline)	<0.0001	<0.0001
Theophylline (μg/mL)
Baseline	0.07 ± 0.11	0.13 ± 0.18	-
Week 6	0.24 ± 0.24	0.27 ± 0.29	0.66
Week 12	0.17 ± 0.17	0.27 ± 0.20	0.49
P value (Week 6 vs. Baseline)	0.0001	0.045
P value (Week 12 vs. Baseline)	0.0003	0.0076
Caffeine (μg/mL)
Baseline	0.29 ± 0.46	0.58 ± 0.82	-
Week 6	1.12 ± 1.27	1.30 ± 2.08	0.78
Week 12	0.82 ± 1.15	1.56 ± 2.05	0.34
P value (Week 6 vs. Baseline)	0.004	0.12
P value (Week 12 vs. Baseline)	0.02	0.03

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