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Table 3 CDRS, CDI, and CGI scores at baseline and after 3 and 6 months in fluoxetine + vitamin C and fluoxetine + placebo groups

From: Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study

Variable

Treatment duration

Vitamin C group

Placebo group

t

P

CDRS

Baseline

30.1 ±3.56

31.3 ±3.89

0.77

0.45

 

3 months

14.4 ±2.39

24.7 ±2.73

9.85

<0.0001

 

6 months

9.0 ±1.50

17.3 ±2.73

11.36

<0.0001

CDI

Baseline

37.3 ±2.38

36.7 ±3.33

−0.42

0.68

 

3 months

15.8 ±2.75

27.0 ±2.30

10.77

<0.0001

 

6 months

9.0 ±1.12

15.5 ±1.45

12.27

<0.0001

CGI

Baseline

54.7 ±7.19

56.3 ±7.23

0.57

0.58

 

3 months

67.1 ±5.04

67.4 ±5.55

0.15

0.88

 

6 months

86.5 ±4.91

86.7 ±4.41

0.13

0.90

  1. Values given are mean ± standard deviation. The statistics listed were measured with t-test. Statistical significance defined as P<0.05. CDI: Children’s Depression Inventory; CDRS: Children’s Depression Rating Scale; CGI: Clinical Global Impression.