|
Variable
|
Tocotrienols (n = 43)
|
Placebo (n = 44)
|
Pvalue
|
|---|
|
Gender (female)
|
23 (53.5%)
|
30 (68.2%)
|
0.160
|
|
Age in years (range)
|
52 ± 9 (36-74)
|
49 ± 7 (38-68)
|
0.177
|
|
BMI (kg/m2)
|
27.2 ± 4.6
|
27.1 ± 4.6
|
0.873
|
|
Normoweight (BMI < 25)
|
16 (37.2%)
|
14 (31.8%)
| |
|
Overweight (25 < BMI < 30)
|
16 (37.2%)
|
21 (47.7%)
| |
|
Obese (30 < BMI < 40)
|
11 (25.6%)
|
8 (18.2%)
| |
|
Morbidly Obese (40 < BMI < 50)
|
0 (0.0%)
|
1 (2.3%)
| |
|
TC (mmol/L)
|
5.9 ± 0.6
|
5.6 ± 0.6
|
0.075
|
|
HDL (mmol/L)
|
1.44 ± 0.35
|
1.37 ± 0.30
|
0.611
|
|
LDL (mmol/L)
|
3.7 ± 0.6
|
3.6 ± 0.6
|
0.168
|
|
TG (mmol/L)
|
1.5 ± 0.7
|
1.6 ± 0.8
|
0.889
|
|
ALP (IU/L)
|
76 ± 21
|
72 ± 18
|
0.826
|
|
AST (IU/L)
|
36 ± 14
|
38 ± 13
|
0.381
|
|
ALT (IU/L)
|
35 ± 16
|
39 ± 22
|
0.611
|
|
GGT (IU/L)
|
33 ± 19
|
32 ± 19
|
0.712
|
|
hs-Crp (mg/L)
|
4.3 ± 7.1
|
4.0 ± 5.4
|
0.865
|
|
Apo B (g/L)
|
1.25 ± 0.20
|
1.25 ± 0.21
|
0.952
|
|
Lp(A) (mg/dL)
|
17 ± 14
|
16 ± 16
|
0.449
|
|
Serum creatinine (μmol/L)
|
86 ± 13
|
78 ± 11
|
0.008
|
|
Fasting glucose (mmol/L)
|
5.4 ± 0.8
|
6.1 ± 2.3
|
0.557
|
|
IFG ≥ 7.0 mmol/L
|
2 (4.7%)
|
7 (15.9%)
| |
|
Systolic (mmHg)
|
134 ± 18
|
131 ± 15
|
0.524
|
|
Diastolic (mmHg)
|
80 ± 9
|
80 ± 9
|
0.976
|
|
Tobacco, current users
|
5 (11.6%)
|
5 (11.4%)
| |
|
Mild NAFLD (score 3)
|
34 (79.1%)
|
35 (79.5%)
| |
|
Moderate NAFLD (score 4)
|
7 (16.3%)
|
8 (18.2%)
| |
|
Severe NAFLD (score 5-6)
|
2 (4.7%)
|
1 (2.3%)
| |
- Baseline biochemical, anthropometric and clinical parameters of all patients enrolled in the study (n = 87). Data are expressed as mean value ± SD; P < 0.05 is considered significant.
- Table 2 Abbreviations: BMI Body Mass Index, TC Total Cholesterol, HDL High Density Lipoprotein, LDL Low Density Lipoprotein, TG Triglycerides, ALP Alkaline Phosphatase, AST aspartate transaminase, ALT alanine transaminase, GGT gamma-glutamyl transpeptidase, hs-CRP high-sensitivity C-reactive protein, ApoB apolipoprotein B, LP(A) lipoprotein A, IFG Impaired Fasting Glucose, NAFLD Nonalcoholic Fatty Liver Disease.
- [Wilcoxon rank test; Numbers’ 09, GraphPad].
- Conversion factor mmol/L to mg/dL for optimal normal values:
- TC 5.2 mmol/L = 200 mg/dL;
- HDL 1.55 mmol/L = 60 mg/dL;
- LDL 2.6 mmol/L = 100 mg/dL;
- TG 1.7 mmol/L = 151 mg/dL.
