Parameter | Vitamin D bread consumption (-12 mo) | Baseline of follow-up study (0 month) | 12 month follow-up | 36-month follow-up | P-value1 | P-value2 | P-value3 |
---|---|---|---|---|---|---|---|
Serum calcium (Normal: 2.15-2.55 mmol/L) | 2.30 ± 0.14 | 2.31 ± 0.13 | 2.26 ± 0.13 | 2.29 ± 0.15 | 0.18 | 0.49 | 0.07 |
Serum 25(OH)D (Sufficiency: 50-125 nmol/l) | 29.8 ± 9.3 | 127.3 ± 37.8 | 64.9 ± 24.8 | 28.0 ± 15.0 | <0.001 | <0.001 | <0.001 |
Serum PTH (Normal: 16-62 pg/ml) | 60.2 ± 42.6 | 18.8 ± 15.6 | 46.7 ± 21.2 | 48.4 ± 18.4 | <0.001 | <0.001 | <0.001 |
Lumbar spine BMD (g/cm2) | 0.825 ± 0.113 | 0.858 ± 0.134 | 0.855 ± 0.146 | 0.867 ± 0.142 | 0.81 | 0.32 | 0.65 |
Total hip BMD (g/cm2) | 0.736 ± 0.128 | 0.927 ± 0.130 | 0.913 ± 0.130 | 0.907 ± 0.121 | 0.02 | 0.02 | 0.14 |