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Table 5 Univariate analysis of the relative abundance of urinary amino acids and derivatives: comparison between participants pre- and post-supplementation

From: Development of a complex amino acid supplement, Fatigue Reviva™, for oral ingestion: initial evaluations of product concept and impact on symptoms of sub-health in a group of males

Amino acid

Pre-supplement relative abundance % mean (SEM)

Post-supplement relative abundance % mean (SEM)

Pvalue

Alanine

5.80 (0.34)

5.09 (0.32)

ns

Glycine

20.82 (1.08)

18.08 (1.58)

ns

α-aminobutyric acid

0.20 (0.05)

0.21 (0.04)

ns

Valine

1.00 (0.06)

1.24 (0.08)

< 0.04

β-aminoisobutyric acid

3.11 (0.49)

4.48 (1.14)

ns

Leucine

0.70 (0.04)

0.70 (0.04)

ns

Isoleucine

0.17 (0.04)

0.35 (0.03)

< 0.02

Threonine

2.45 (0.14)

2.35 (0.16)

ns

Serine

5.94 (0.39)

5.42 (0.37)

ns

Proline

0.31 (0.07)

0.51 (0.08)

< 0.04

Asparagine

5.32 (0.35)

5.25 (0.52)

ns

Aspartic acid

0.34 (0.08)

0.48 (0.06)

ns

Methionine

0.29 (0.04)

0.35 (0.04)

ns

Hydroxyproline

0.41 (0.07)

0.56 (0.08)

ns

Glutamic acid

0.33 (0.07)

0.70 (0.09)

< 0.008

Phenylalanine

1.07 (0.07)

1.20 (0.10)

ns

α-aminoadipic acid

1.86 (0.33)

1.65 (0.29)

ns

α-aminopimelic acid

0.15 (0.05)

0.10 (0.03)

ns

Glutamine

12.61 (0.85)

8.75 (0.62)

< 0.003

Ornithine

1.22 (0.11)

0.99 (0.10)

< 0.04

Glycine-proline dipeptide

2.06 (0.22)

1.99 (0.22)

ns

Lysine

6.53 (1.54)

6.36 (1.88)

ns

Histidine

17.70 (1.12)

22.59 (2.71)

ns

Hydroxylysine

1.29 (0.12)

1.44 (0.16)

ns

Tyrosine

1.92 (0.13)

2.07 (0.16)

ns

Proline-hydroxyproline dipeptide

3.04 (0.38)

2.84 (0.31)

ns

Tryptophan

1.31 (0.10)

1.40 (0.11)

ns

Cystathionine

0.86 (0.18)

1.37 (0.33)

ns

Cystine

1.21 (0.12)

1.47 (0.20)

ns

Total EAA

31.22 (1.38)

36.55 (2.79)

< 0.05

Total BCAA

1.87 (0.13)

2.29 (0.11)

< 0.02

  1. Statistical test: Mann–Whitney U test, P < 0.05. Values are the mean (SEM) and are expressed as amino acid relative abundance (percentage). Analysis performed on arcsine transformed data. ns = statistically non-significant.