Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth

Table 1 Selected milk-derived miRs and their potential impact on metabolism

Milk-derived miR	Ref.	miR function in metabolism	Ref.
miR-21	50	miR-21: Inhibition of various tumor suppressor gene mRNAs (PTEN, Spouty1, Sprouty2, PDCD4)	[63–72, 75]
miR-21	50	Increased adipogenesis	[100–102]
miR-29a	54	miR-29a: Down-regulation of Insig-1 with increased lipogenesis and adipocyte differentiation	[106]
miR-29a	54		[107, 108]
miR-29b	51	miR-29b: Reduction of BCKD and reduced BCAA catabolism	[111]
miR-29b	51	miR-29b: Reduction of BCKD and reduced BCAA catabolism	[110]
miR-103	51	miR-103: Increased adipogenesis	[100, 105]
miR-155	51	miR-155: Reduction of brown adipose tissue and thermogenesis	[109]
Let-7a, b, c, f	51	Let-7: overexpression results in insulin resistance and disturbed glucose homeostasis	[120, 122]

ISSN: 1475-2891