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Table 3 Sex hormone-binding globulin and endogenous sex hormones by treatment group at week 4 and week 8 in women
| Week 4 | Week 8 | |||||
|---|---|---|---|---|---|---|
| Value (95% confidence interval) | Value (95% confidence interval) | |||||
| Caffeinated | Decaffeinated | No Coffee | Caffeinated | Decaffeinated | No Coffee | |
| Coffee | Coffee | Coffee | Coffee | Coffee | ||
| (N = 10) | (N = 9) | (N = 9) | (N = 10) | (N = 9) | (N = 9) | |
| SHBG (nmol/L) | ||||||
| Geometric means† | 43.8 (35.2, 54.5) | 52.8 (42.5, 65.5) | 38.2 (30.7, 47.6) | 44.2 (37.3, 52.4) | 45.8 (38.7, 54.1) | 44.2 (37.3, 52.4) |
| Difference in CFB (%)‡ | 14.6 (−16.2, 56.7) | 38.0 (1.5, 87.7) a | Reference | −0.0 (−21.6, 27.4) | 3.6 (−18.4, 31.5) | Reference |
| Testosterone (ng/dL) | ||||||
| Geometric means† | 51.3 (33.5, 78.6) | 39.0 (24.8, 61.4) | 98.3 (62.3, 155.2) | 35.1 (26.2, 47.0) | 32.4 (23.8, 44.2) | 37.3 (27.3, 51.0) |
| Difference in CFB (%)‡ | −47.8 (−72.1, -2.3) a | −60.3 (−79.3, -24.0) b | Reference | −5.9 (−38.7, 44.3) | −13.1 (−44.3, 35.5) | Reference |
| Free testosterone (ng/dL) | ||||||
| Geometric means† | 0.6 (0.3, 1.0) | 0.4 (0.2, 0.7) | 1.2 (0.7, 2.1) | 0.4 (0.3, 0.6) | 0.3 (0.2, 0.5) | 0.4 (0.3, 0.6) |
| Difference in CFB (%)‡ | −51.1 (−78.7, 12.0) | −67.8 (−86.0, -26.2) b | Reference | −6.0 (−47.5, 68.5) | −13.3 (−51.6, 55.4) | Reference |
| Estradiol (pg/mL) | ||||||
| Geometric means† | 37.9 (26.5, 54.2) | 42.6 (29.0, 62.3) | 42.9 (28.7, 64.1) | 41.8 (24.8, 70.6) | 39.7 (22.7, 69.4) | 40.6 (23.3, 70.6) |
| Difference in CFB (%)‡ | −11.8 (−48.4, 50.8) | −0.9 (−43.2, 73.2) | Reference | 3.2 (−51.7, 120.5) | −2.1 (−55.8, 116.6) | Reference |
| Free estradiol (pg/mL) | ||||||
| Geometric means† | 0.6 (0.4, 0.9) | 0.6 (0.4, 0.9) | 0.7 (0.5, 1.1) | 0.7 (0.4, 1.1) | 0.6 (0.3, 1.0) | 0.6 (0.4, 1.1) |
| Difference in CFB (%)‡ | −19.3 (−56.1, 48.3) | −13.4 (−53.5, 61.3) | Reference | 2.9 (−52.2, 121.6) | −5.2 (−56.8, 108.2) | Reference |
| Testosterone : Estradiol | ||||||
| Geometric means† | 1.4 (0.8, 2.3) | 1.0 (0.6, 1.7) | 2.1 (1.2, 3.8) | 0.8 (0.5, 1.5) | 0.8 (0.4, 1.5) | 0.9 (0.5, 1.7) |
| Difference in CFB (%)‡ | −36.0 (−71.0, 41.4) | −54.1 (−79.6, 3.3) | Reference | −9.9 (−61.7, 111.9) | −9.6 (−62.6, 118.3) | Reference |
| DHEAs (ng/mL) | ||||||
| Geometric means† | 113.8 (101.0, 128.1) | 101.7 (89.6, 115.5) | 100.0 (87.5, 114.4) | 111.7 (101.0, 123.6) | 102.9 (92.3, 114.6) | 120.4 (108.2, 134.1) |
| Difference in CFB (%)‡ | 13.7 (−4.9, 36.0) | 1.7 (−15.6, 22.5) | Reference | −7.2 (−19.9, 7.4) | −14.6 (−26.7, -0.4) | Reference |
