| |
Week 4
|
Week 8
|
|---|
|
Value (95% confidence interval)
|
Value (95% confidence interval)
|
|---|
| |
Caffeinated
|
Decaffeinated
|
No Coffee
|
Caffeinated
|
Decaffeinated
|
No Coffee
|
|---|
| |
Coffee
|
Coffee
|
Coffee
|
Coffee
|
Coffee
| |
|---|
| |
(N = 10)
|
(N = 9)
|
(N = 9)
|
(N = 10)
|
(N = 9)
|
(N = 9)
|
|---|
|
SHBG (nmol/L)
|
|
Geometric means†
|
43.8 (35.2, 54.5)
|
52.8 (42.5, 65.5)
|
38.2 (30.7, 47.6)
|
44.2 (37.3, 52.4)
|
45.8 (38.7, 54.1)
|
44.2 (37.3, 52.4)
|
|
Difference in CFB (%)‡
|
14.6 (−16.2, 56.7)
|
38.0 (1.5, 87.7) a
|
Reference
|
−0.0 (−21.6, 27.4)
|
3.6 (−18.4, 31.5)
|
Reference
|
|
Testosterone (ng/dL)
|
|
Geometric means†
|
51.3 (33.5, 78.6)
|
39.0 (24.8, 61.4)
|
98.3 (62.3, 155.2)
|
35.1 (26.2, 47.0)
|
32.4 (23.8, 44.2)
|
37.3 (27.3, 51.0)
|
|
Difference in CFB (%)‡
|
−47.8 (−72.1, -2.3) a
|
−60.3 (−79.3, -24.0) b
|
Reference
|
−5.9 (−38.7, 44.3)
|
−13.1 (−44.3, 35.5)
|
Reference
|
|
Free testosterone (ng/dL)
|
|
Geometric means†
|
0.6 (0.3, 1.0)
|
0.4 (0.2, 0.7)
|
1.2 (0.7, 2.1)
|
0.4 (0.3, 0.6)
|
0.3 (0.2, 0.5)
|
0.4 (0.3, 0.6)
|
|
Difference in CFB (%)‡
|
−51.1 (−78.7, 12.0)
|
−67.8 (−86.0, -26.2) b
|
Reference
|
−6.0 (−47.5, 68.5)
|
−13.3 (−51.6, 55.4)
|
Reference
|
|
Estradiol (pg/mL)
|
|
Geometric means†
|
37.9 (26.5, 54.2)
|
42.6 (29.0, 62.3)
|
42.9 (28.7, 64.1)
|
41.8 (24.8, 70.6)
|
39.7 (22.7, 69.4)
|
40.6 (23.3, 70.6)
|
|
Difference in CFB (%)‡
|
−11.8 (−48.4, 50.8)
|
−0.9 (−43.2, 73.2)
|
Reference
|
3.2 (−51.7, 120.5)
|
−2.1 (−55.8, 116.6)
|
Reference
|
|
Free estradiol (pg/mL)
|
|
Geometric means†
|
0.6 (0.4, 0.9)
|
0.6 (0.4, 0.9)
|
0.7 (0.5, 1.1)
|
0.7 (0.4, 1.1)
|
0.6 (0.3, 1.0)
|
0.6 (0.4, 1.1)
|
|
Difference in CFB (%)‡
|
−19.3 (−56.1, 48.3)
|
−13.4 (−53.5, 61.3)
|
Reference
|
2.9 (−52.2, 121.6)
|
−5.2 (−56.8, 108.2)
|
Reference
|
|
Testosterone : Estradiol
|
|
Geometric means†
|
1.4 (0.8, 2.3)
|
1.0 (0.6, 1.7)
|
2.1 (1.2, 3.8)
|
0.8 (0.5, 1.5)
|
0.8 (0.4, 1.5)
|
0.9 (0.5, 1.7)
|
|
Difference in CFB (%)‡
|
−36.0 (−71.0, 41.4)
|
−54.1 (−79.6, 3.3)
|
Reference
|
−9.9 (−61.7, 111.9)
|
−9.6 (−62.6, 118.3)
|
Reference
|
|
DHEAs (ng/mL)
|
|
Geometric means†
|
113.8 (101.0, 128.1)
|
101.7 (89.6, 115.5)
|
100.0 (87.5, 114.4)
|
111.7 (101.0, 123.6)
|
102.9 (92.3, 114.6)
|
120.4 (108.2, 134.1)
|
|
Difference in CFB (%)‡
|
13.7 (−4.9, 36.0)
|
1.7 (−15.6, 22.5)
|
Reference
|
−7.2 (−19.9, 7.4)
|
−14.6 (−26.7, -0.4)
|
Reference
|
-
SHBG, sex hormone-binding globulin; CFB, change from baseline; DHEAs, dehydroepiandrosterone sulfate.
-
† Geometric mean as the dependent variable with treatment as a main effect, and baseline log value (grand mean centered) and age (grand mean centered) as covariates.
-
‡ Difference in change from baseline compared to No Coffee (i.e., ratio of ratios) adjusted for the above covariates.
-
a p < 0.05 compared to No Coffee.
-
b p < 0.01 compared to No Coffee.
