| |
Week 4
|
Week 8
|
|---|
| |
Value (95% confidence interval)
|
Value (95% confidence interval)
|
|---|
| |
Caffeinated
|
Decaffeinated
|
No Coffee
|
Caffeinated
|
Decaffeinated
|
No Coffee
|
|---|
| |
Coffee
|
Coffee
|
Coffee
|
Coffee
|
Coffee
| |
|---|
| |
(N = 4)
|
(N = 4)
|
(N = 6)
|
(N = 4)
|
(N = 4)
|
(N = 6)
|
|---|
|
SHBG (nmol/L)
|
|
Geometric means†
|
20.7 (15.2, 28.1)
|
23.9 (16.7, 34.2)
|
23.0 (16.3, 32.4)
|
23.1 (19.4, 27.5)
|
25.0 (20.4, 30.6)
|
23.1 (19.0, 28.0)
|
|
Difference in CFB (%)‡
|
−10.2 (−44.7, 45.7)
|
3.8 (−39.3, 77.4)
|
Reference
|
0.2 (−23.8, 31.8)
|
8.2 (−20.1, 46.5)
|
Reference
|
|
Testosterone (ng/dL)
|
|
Geometric means†
|
546.2 (412.8, 722.7)
|
493.6 (350.5, 695.1)
|
327.4 (227.7, 470.8)
|
403.8 (349.8, 466.0)
|
386.1 (324.0, 460.1)
|
373.1 (309.8, 449.5)
|
|
Difference in CFB (%)‡
|
66.8 (3.9, 167.9) a
|
50.8 (−13.1, 161.6)
|
Reference
|
8.2 (−15.1, 37.9)
|
3.5 (−22.0, 37.2)
|
Reference
|
|
Free testosterone (ng/dL)
|
|
Geometric means†
|
11.7 (7.0, 19.6)
|
9.2 (5.1, 16.8)
|
6.6 (3.6, 12.2)
|
8.0 (6.6, 9.6)
|
7.6 (6.1, 9.5)
|
7.0 (5.6, 8.7)
|
|
Difference in CFB (%)‡
|
76.0 (−21.8, 295.9)
|
39.0 (−42.8, 238.0)
|
Reference
|
14.5 (−14.9, 54.1)
|
9.7 (−20.8, 51.9)
|
Reference
|
|
Estradiol (pg/mL)
|
|
Geometric means†
|
22.5 (17.2, 29.5)
|
35.9 (26.3, 49.0)
|
42.6 (30.9, 58.7)
|
25.2 (19.3, 32.8)
|
27.1 (20.0, 36.9)
|
20.7 (15.1, 28.4)
|
|
Difference in CFB (%)‡
|
−47.1 (−65.5, -19.1) b
|
−15.8 (−47.3, 34.5)
|
Reference
|
21.7 (−20.0, 85.3)
|
31.2 (−17.4, 108.2)
|
Reference
|
|
Free estradiol (pg/mL)
|
|
Geometric means†
|
0.4 (0.3, 0.6)
|
0.7 (0.5, 0.9)
|
0.8 (0.6, 1.1)
|
0.5 (0.4, 0.6)
|
0.5 (0.4, 0.71)
|
0.4 (0.3, 0.6)
|
|
Difference in CFB (%)‡
|
−42.8 (−63.7, -9.9) a
|
−12.7 (−46.5, 42.4)
|
Reference
|
21.4 (−21.9, 88.8)
|
31.1 (−18.5, 110.9)
|
Reference
|
|
Testosterone : Estradiol
|
|
Geometric means†
|
24.2 (15.2, 38.4)
|
12.6 (7.5, 21.4)
|
8.4 (4.8, 14.5)
|
16.1 (12.2, 21.3)
|
14.6 (10.6, 20.1)
|
17.5 (12.5, 24.4)
|
|
Difference in CFB (%)‡
|
188.8 (38.5, 502.1) b
|
50.9 (−31.7, 233.6)
|
Reference
|
−8.0 (−41.1, 43.8)
|
−16.6 (−48.5, 35.1)
|
Reference
|
|
DHEAs (ng/mL)
|
|
Geometric means†
|
178.0 (161.1, 196.8)
|
165.4 (147.7, 185.3)
|
159.8 (143.7, 177.6)
|
193.9 (168.1, 223.7)
|
164.1 (139.6, 193.0)
|
162.9 (140.1, 189.5)
|
|
Difference in CFB (%)‡
|
11.4 (−4.2, 29.5)
|
3.5 (−12.0, 21.7)
|
Reference
|
19.0 (−4.0, 47.6)
|
0.7 (−20.1, 27.0)
|
Reference
|
-
SHBG, sex hormone-binding globulin; CFB, change from baseline; DHEAs, dehydroepiandrosterone sulfate.
-
† Geometric mean as the dependent variable with treatment as a main effect, and baseline log value (grand mean centered) and age (grand mean centered) as covariates.
-
‡ Difference in change from baseline compared to No Coffee (i.e., ratio of ratios) adjusted for the above covariates.
-
a p < 0.05 compared to No Coffee.
-
b p < 0.01 compared to No Coffee.
