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Table 2 Sex hormone-binding globulin and endogenous sex hormones by treatment group at week 4 and week 8 in men
| Week 4 | Week 8 | |||||
|---|---|---|---|---|---|---|
| Value (95% confidence interval) | Value (95% confidence interval) | |||||
| Caffeinated | Decaffeinated | No Coffee | Caffeinated | Decaffeinated | No Coffee | |
| Coffee | Coffee | Coffee | Coffee | Coffee | ||
| (N = 4) | (N = 4) | (N = 6) | (N = 4) | (N = 4) | (N = 6) | |
| SHBG (nmol/L) | ||||||
| Geometric means† | 20.7 (15.2, 28.1) | 23.9 (16.7, 34.2) | 23.0 (16.3, 32.4) | 23.1 (19.4, 27.5) | 25.0 (20.4, 30.6) | 23.1 (19.0, 28.0) |
| Difference in CFB (%)‡ | −10.2 (−44.7, 45.7) | 3.8 (−39.3, 77.4) | Reference | 0.2 (−23.8, 31.8) | 8.2 (−20.1, 46.5) | Reference |
| Testosterone (ng/dL) | ||||||
| Geometric means† | 546.2 (412.8, 722.7) | 493.6 (350.5, 695.1) | 327.4 (227.7, 470.8) | 403.8 (349.8, 466.0) | 386.1 (324.0, 460.1) | 373.1 (309.8, 449.5) |
| Difference in CFB (%)‡ | 66.8 (3.9, 167.9) a | 50.8 (−13.1, 161.6) | Reference | 8.2 (−15.1, 37.9) | 3.5 (−22.0, 37.2) | Reference |
| Free testosterone (ng/dL) | ||||||
| Geometric means† | 11.7 (7.0, 19.6) | 9.2 (5.1, 16.8) | 6.6 (3.6, 12.2) | 8.0 (6.6, 9.6) | 7.6 (6.1, 9.5) | 7.0 (5.6, 8.7) |
| Difference in CFB (%)‡ | 76.0 (−21.8, 295.9) | 39.0 (−42.8, 238.0) | Reference | 14.5 (−14.9, 54.1) | 9.7 (−20.8, 51.9) | Reference |
| Estradiol (pg/mL) | ||||||
| Geometric means† | 22.5 (17.2, 29.5) | 35.9 (26.3, 49.0) | 42.6 (30.9, 58.7) | 25.2 (19.3, 32.8) | 27.1 (20.0, 36.9) | 20.7 (15.1, 28.4) |
| Difference in CFB (%)‡ | −47.1 (−65.5, -19.1) b | −15.8 (−47.3, 34.5) | Reference | 21.7 (−20.0, 85.3) | 31.2 (−17.4, 108.2) | Reference |
| Free estradiol (pg/mL) | ||||||
| Geometric means† | 0.4 (0.3, 0.6) | 0.7 (0.5, 0.9) | 0.8 (0.6, 1.1) | 0.5 (0.4, 0.6) | 0.5 (0.4, 0.71) | 0.4 (0.3, 0.6) |
| Difference in CFB (%)‡ | −42.8 (−63.7, -9.9) a | −12.7 (−46.5, 42.4) | Reference | 21.4 (−21.9, 88.8) | 31.1 (−18.5, 110.9) | Reference |
| Testosterone : Estradiol | ||||||
| Geometric means† | 24.2 (15.2, 38.4) | 12.6 (7.5, 21.4) | 8.4 (4.8, 14.5) | 16.1 (12.2, 21.3) | 14.6 (10.6, 20.1) | 17.5 (12.5, 24.4) |
| Difference in CFB (%)‡ | 188.8 (38.5, 502.1) b | 50.9 (−31.7, 233.6) | Reference | −8.0 (−41.1, 43.8) | −16.6 (−48.5, 35.1) | Reference |
| DHEAs (ng/mL) | ||||||
| Geometric means† | 178.0 (161.1, 196.8) | 165.4 (147.7, 185.3) | 159.8 (143.7, 177.6) | 193.9 (168.1, 223.7) | 164.1 (139.6, 193.0) | 162.9 (140.1, 189.5) |
| Difference in CFB (%)‡ | 11.4 (−4.2, 29.5) | 3.5 (−12.0, 21.7) | Reference | 19.0 (−4.0, 47.6) | 0.7 (−20.1, 27.0) | Reference |
