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Table 2 Comparison of fatigue, plasma vitamin C levels, and oxidative stress between the two groups.

From: Intravenous Vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial

  Vitamin C Group
(n = 70)
Placebo Group
(n = 71)
p value
  Baseline 2 hours after intervention 1 day after intervention Baseline 2 hours after intervention 1 day after intervention  
Fatigue right now* 5.64 ± 2.02 5.10 ± 2.04 4.97 ± 2.33 5.54 ± 2.07 5.31 ± 2.00 5.66 ± 2.16 0.004
Usual fatigue during the previous 24 hours 5.59 ± 1.56 - 5.37 ± 2.06 5.77 ± 1.73 - 5.55 ± 1.79 0.870
Worst fatigue during the previous 24 hours 7.16 ± 1.83 - 6.47 ± 2.13 7.14 ± 1.77 - 6.82 ± 1.97 0.202
Plasma vitamin C level (μg/ml) 12.66 ± 6.50 267.90 ± 141.83 - 12.13 ± 4.99 12.52 ± 5.70 - < 0.001
Oxidative stress (mmol/dl H2O2) 311.76 ± 74.15 184.46 ± 59.41 296.11 ± 64.37 310.89 ± 74.90 327.21 ± 78.80 303.72 ± 81.26 < 0.001
  1. *Fatigue was measured using a numeric rating scale, 0-10.
  2. †Oxidative stress was measured using the Free Oxygen Radicals Test (FORT).
  3. ‡p value from ANCOVA.