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Table 1 Hazard ratios for disease progression in breast cancer patients

From: Prognosis of breast cancer is associated with one-carbon metabolism related nutrients among Korean women

 

All (N = 980)

Events (N = 141)

Model 1a

Model 2b

Age (mean(SD))

48 (9.8)

49 (11.7)

1.02 (1.00-1.04)

1.01 (0.99-1.03)

 ≤39

191 (19.5)

30 (21.3)

1.00

1.00

 40-49

422 (43.0)

50 (35.5)

0.86 (0.54-1.36)

0.76 (0.48-1.22)

 50-59

241 (24.6)

34 (24.1)

1.02 (0.62-1.70)

0.83 (0.48-1.42)

 ≥60

126 (12.9)

27 (19.1)

1.66 (0.97-2.82)

1.21 (0.67-2.18)

Menopausal status

    

 Pre

610 (63.0)

74 (53.6)

1.00

1.00

 Post

359 (37.0)

64 (46.4)

1.50 (0.93-2.42)

1.38 (0.85-2.25)

BMI, kg/m2 (mean(SD))

23 (2.9)

23 (3.2)

0.98 (0.92-1.04)

0.97 (0.91-1.03)

 <25

753 (77.6)

107 (77.0)

1.00

1.00

 ≥25

217 (22.4)

32 (23.0)

0.85 (0.56-1.28)

0.79 (0.52-1.20)

Education

    

 Middle school

224 (22.9)

46 (32.6)

1.00

1.00

 High school

402 (41.2)

56 (39.7)

0.68 (0.45-1.05)

0.69 (0.45-1.05)

 College

351 (35.9)

39 (27.7)

0.58 (0.36-0.94)

0.58 (0.36-0.93)

Alcohol drinking

    

 <1/month

559 (57.5)

85 (60.7)

1.00

1.00

 1-3/month

354 (36.4)

46 (32.9)

0.83 (0.57-1.21)

0.83 (0.57-1.22)

 1+/week

59 (6.1)

9 (6.4)

1.12 (0.56-2.25)

1.09 (0.54-2.19)

Recruited sites

    

 SNU

511 (52.1)

73 (51.8)

1.00

1.00

 AMC

469 (47.9)

68 (48.2)

0.92 (0.65-1.30)

0.89 (0.63-1.26)

TNM stage

    

 I

400 (40.8)

25 (17.7)

1.00

1.00

 II

416 (42.5)

72 (51.1)

2.78 (1.74-4.44)

2.71 (1.69-4.35)

 III

164 (16.7)

44 (31.2)

4.27 (2.57-7.11)

4.17 (2.50-6.96)

Tumor size

    

 <2 cm

526 (54.9)

42 (29.8)

1.00

1.00

 ≥2 cm

431 (44.9)

99 (70.2)

2.57 (1.74-3.79)

2.51 (1.70-3.72)

 Tx

2 (0.2)

   

Lymph node status

    

 Negative

577 (58.9)

60 (42.6)

1.00

1.00

 Positive

390 (39.8)

78 (55.3)

1.47 (1.03-2.11)

1.46 (1.02-2.09)

 Nx

13 (1.3)

3 (2.1)

  

Hormone status

    

 ER + and/or PR+

698 (72.6)

74 (53.6)

1.00

1.00

 ER–/PR–

264 (27.4)

64 (46.4)

2.06 (1.41-3.01)

2.06 (1.40-3.02)

Nuclear grade

    

 I-II

525 (55.2)

57 (41.0)

1.00

1.00

 III

426 (44.8)

82 (59.0)

1.15 (0.78-1.69)

1.12 (0.75-1.65)

  1. Abbreviation: AMC, Asan Medical Center; ER, estrogen receptor; PR, progesterone receptor; SNU, Seoul National University.
  2. Data are presented as frequency (percentage), except for age and BMI in continuous variable, which are expressed as mean (SD).
  3. a Adjusted for age, TNM stage and hormone status and nuclear grade.
  4. b Adjusted for age, education, recruited site, TNM stage, hormone status and nuclear grade.
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Nutrition Journal

ISSN: 1475-2891

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