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Table 2 Differences in measured outcomes between early and late feeding groups and break down by illness severity

From: Association between illness severity and timing of initial enteral feeding in critically ill patients: a retrospective observational study

Measured outcomes

Early

Late

APACHE II <20

APACHE II ≥20

 

(n = 40)

(n = 68)

(n = 47)

(n = 61)

   

Early

Late

Early

Late

   

(n = 14)

(n = 33)

(n = 26)

(n = 35)

Clinical outcomes

      

  Frequency of feeding complications (times/d)

0.11 ± 0.18

0.08 ± 0.18

0.05 ± 0.12

0.10 ± 0.24

0.14 ± 0.20

0.05 ± 0.11**

  VAP (%, n)

32.5 (13/40)

13.8 (9/65)*

28.6 (4/14)

9.1 (3/33)

34.6 (9/26)

18.8 (6/32)

  Length of ICU stay (d)

21.1 ± 14.3

15.0 ± 7.7*

16.4 ± 13.3

15.9 ± 9.1

23.6 ± 14.4

14.2 ± 6.0**

  Length of hospital stay (d)

37.0 ± 26.2

33.07 ± 23.1

24.1 ± 17.4

34.8 ± 27.3

43.9 ± 27.8

31.4 ± 18.5

  Hospital mortality (%, n)

45.0 (18/40)

36.8 (25/68)

35.7 (5/14)

18.2 (6/33)

50.0 (13/26)

54.3 (19/35)

Nutritional outcomes

      

  % of target caloric intake

86.9 ± 21.7

82.2 ± 26.3

85.3 ± 19.5

84.4 ± 24.4

87.8 ± 23.1

80.1 ± 28.2

  % of target protein intake

89.6 ± 26.6

85.7 ± 32.5

84.9 ± 18.7

84.6 ± 28.6

92.1 ± 30.1

86.7 ± 36.1

  Albumin on 7th feeding day (g/L)

20.9 ± 4.8

20.0 ± 5.1

21.4 ± 5.8

21.9 ± 3.8

20.7 ± 4.5

18.2 ± 5.6*

 

(n = 35)

(n = 47)

(n = 10)

(n = 23)

(n = 25)

(n = 24)

  Prealbumin on 4th feeding day (mg/dL)

16.3 ± 13.3

14.1 ± 8.3*

16.1 ± 8.6

16.2 ± 7.3

13.3 ± 3.5

12.1 ± 8.8*

 

(n = 40)

(n = 65)

(n = 14)

(n = 32)

(n = 26)

(n = 33)

  Prealbumin on 7th feeding day (mg/dL)

15.4 ± 5.4

14.0 ± 7.7

14.9 ± 7.0

16.3 ± 8.5

15.6 ± 4.7

11.9 ± 6.5*

 

(n = 34)

(n = 46)

(n = 10)

(n = 22)

(n = 24)

(n = 24)

  NB on 7th feeding day (g/d)

−8.0 ± 7.9

−3.7 ± 5.3**

−10.2 ± 7.5

−3.6 ± 5.3**

−7.1 ± 8.0

−3.7 ± 5.5

 

(n = 34)

(n = 45)

(n = 10)

(n = 23)

(n = 24)

(n = 22)

  NB on 14th feeding day (g/d)

−6.8 ± 5.9

−1.6 ± 4.6**

−5.1 ± 5.7

−2.4 ± 5.4

−7.5 ± 6.0

−0.8 ± 3.8**

 

(n = 19)

(n = 19)

(n = 5)

(n = 9)

(n = 14)

(n = 10)

  24-h UUN on 14th feeding day (g/d)

12.8 ± 4.3

8.3 ± 4.9**

12.7 ± 7.0

9.3 ± 5.0

12.8 ± 3.2

7.4 ± 4.8**

 

(n = 19)

(n = 19)

(n = 5)

(n = 9)

(n = 14)

(n = 10)

  24-h UUN on 21st feeding day (g/d)

9.5 ± 2.9

5.5 ± 3.0*

12.4 ± 3.9

7.6 ± 1.4

8.6 ± 2.1

2.4 ± 0.2*

 

(n = 13)

(n = 5)

(n = 3)

(n = 3)

(n = 10)

(n = 2)

  1. APACHE, Acute Physiology and Chronic Health Evaluation; VAP, ventilator-associated pneumonia; ICU, intensive care unit. Data are expressed as mean ± SD, percentage, and number of patients in parentheses. Student’s t-test for differences between early and late feeding groups, and Mann–Whitney U-test for differences between both feeding groups categorized by APACHE II <20 and APACHE II ≥20. Single asterisk (*) indicates p < 0.05, double asterisks (**) indicate p < 0.01.