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Table 1 Demographic and clinical characteristics of the patients categorized by timing of feeding initiation and break down by illness severity

From: Association between illness severity and timing of initial enteral feeding in critically ill patients: a retrospective observational study

Characteristic

  

APACHE II <20

APACHE II ≥20

 

Early

Late

    
   

(n = 47)

(n = 61)

 

(n = 40)

(n = 68)

    
   

Early

Late

Early

Late

   

(n = 14)

(n = 33)

(n = 26)

(n = 35)

Gender (M/F), n

M 27

M 53

M 8

M 26

M 19

M 27

 

F 13

F 15

F 6

F 7

F 7

F 8

Age (y)

72.8 ± 11.1

67.5 ± 15.9*

64.1 ± 13.6

62.3 ± 15.2

77.5 ± 5.5

72.4 ± 15.2

Body mass index (kg/m 2 )

23.1 ± 4.4

23.5 ± 5.5

25.4 ± 4.6

24.5 ± 6.1

21.8 ± 3.8

22.6 ± 4.8

Diagnosis at ICU admission, n

      

  Cardiovascular

7

12

2

5

5

7

  Respiratory

20

30

7

15

13

15

  Gastrointestinal

3

9

1

3

2

6

  Neurological

3

10

1

6

2

4

  Sepsis

4

5

1

3

3

2

  Others

3

2

2

1

1

1

Mechanical ventilation, n (%)

40 (100)

68 (100)

14 (100)

33 (100)

26 (100)

35 (100)

Admission to feeding initiation (h)

45.6 ± 7.3

109.4 ± 47.7 ***

48.0 ± 0.0

109.1 ± 46.1 ***

44.3 ± 8.8

109.7 ± 53.4 ***

Enteral feeding route, n

      

  NG tube feeding

23

35

6

18

17

17

  ND tube feeding

17

33

8

15

9

18

Recommended energy requirement (kcal/d)

1718 ± 174

1757 ± 184

1721 ± 193

1755 ± 172

1715 ± 167

1760 ± 197

Recommended protein requirement (g/d)

69.5 ± 12.4

69.1 ± 12.4

71.4 ± 12.3

70.6 ± 11.6

68.4 ± 12.6

67.7 ± 13.0

APACHE II score at ICU admission

21.4 ± 6.2

20.4 ± 7.1

15.3 ± 3.2

14.6 ± 2.8

24.7 ± 4.8

25.9 ± 5.4

Patients taking prokinetic agents, n (%)

13 (32.5)

23 (33.8)

3 (21.4)

12 (36.4)

10 (38.5)

11 (31.4)

Patients taking PPIs or H 2 antagonists, n (%)

15 (37.5)

17 (25.0)

4 (28.6)

7 (21.2)

11 (42.3)

10 (28.6)

Patients taking antibiotics, n (%)

39 (97.5)

54 (79.4) **

14 (100)

26 (78.8)**

25 (96.2)

28 (80)*

  1. APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; NG, nasogastric; ND, nasoduodenal; PPI, proton pump inhibitor.
  2. Data are expressed as mean ± SD, number of patients, or percentage in parentheses. Student’s t-test for differences between early and late feeding groups, Mann–Whitney U-test for differences between early and late feeding groups categorized by APACHE II <20 and APACHE II ≥20. Single asterisk (*) indicates p < 0.05, double asterisks (**) indicate p < 0.01, and triple asterisks (***) indicate p < 0.001.