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Table 1 Composition of the studied TPN

From: Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use

Nutrients

Concentration (volume of stock solution)

NP1

NP2

NP3

Pediatric aminoacids solution 10% (v/v)with taurine

30 mg/mL(30 mL)

30 mg/mL(30 mL)

30 mg/mL(30 mL)

Dextrose solution 50% (v/v)

80 mg/mL(17.3 mL)

80 mg/mL(17.3 mL)

80 mg/mL(17.3 mL)

LCT/MCT lipid emulsion 20% (v/v)

30 mg/mL(15 mL)

30 mg/mL (15 mL)

30 mg/mL(15 mL)

Sodium chloride injection USP

235 mg/mL(1.2 mL)

235 mg/mL(1.2 mL)

235 mg/mL(1.2 mL)

Calcium gluconate injection USP

3 mg/mL(3 mL)

3 mg/mL(3 mL)

3 mg/mL(3 mL)

Organic phosphate

1.2 mg/mL(0.5 mL)

1.2 mg/mL(0.5 mL)

1.2 mg/mL(0.5 mL)

Magnesium sulphate injection, USP

0.15 mg/mL(0.25 mL)

0.15 mg/mL(0.25 mL)

0.15 mg/mL(0.25 mL)

Trace elements (Cu, Cr, Zn, Mn – Ped Element)

Cu

-----

0.2 μg/mL

0.2 μg/mL

Cr

0.002 μg/mL

0.002 μg/mL

Mn

0.02 μg/mL

0.02 μg/mL

Zn

0.5 μg/mL

0.5 μg/mL

(0.2 mL)

(0.2 mL)

Zinc acetate

-----

3 μg/mL(1.5 mL)

3 μg/mL(1.5 mL)

 

Vitamins(MVI 12 opoplex)

A

1.3 μg/mL

-------

1.3 μg/mL

D

5 μg/mL

5 μg/mL

E

10 μg/mL

10 μg/mL

B1

3 μg/mL

3 μg/mL

B2

3.6 μg/mL

3.6 μg/mL

B3

40 μg/mL

40 μg/mL

B5

15 μg/mL

15 μg/mL

B6

4 μg/mL

4 μg/mL

B7

60 μg/mL

60 μg/mL

B9

400 μg/mL

400 μg/mL

B12

5 μg/mL

5 μg/mL

C

100 μg/mL

100 μg/mL

(0.5 mL)

(0.5 mL)

Final volume q.s.

100 mL

100 mL

100 mL