MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults

Table 3 Response of plasma Homocysteine to different doses and duration of folic acid supplementation by MTR A2756G genotypes

	N	Homocysteine, μmol/L¹ Percent relative change of homocysteine²			Difference in change of Homocysteine at 4 weeks by genotypes³			Difference in change of Homocysteine at 8 weeks by genotypes³
		baseline	4 weeks	8 weeks	β	SE	P	β	SE	P
Control
AA	130	12.8(1.6)[12.0]	12.9(1.6)[11.7]	12.9(1.6)[12.0]
			1.7(15.1)	2.33(17.7)	ref			ref		.
AG/GG	22	12.1(1.5)[11.7]	12.6(6.8)[1.6]	12.6(1.5)[12.2]
			5.8(15.2)	6.32(20.1)	5.17	3.50	0.139	6.08	4.10	0.138
Total	152	12.7(1.6)[12.0]	12.8(1.6)[11.7]	12.8(1.6)[12.0]
			2.3(15.1)	2.9(18.0)
Low FA
AA	116	12.9(1.6)[11.5]	11.5(1.5)[11.1]*	11.3(1.5)[10.6] *
			-9.4(16.5)	-10.2(19.4)	ref			ref
AG/GG	31	14.1(1.5)[14.5]	13.1(1.5)[12.3]	12.5(1.5)[12.3] *^$
			-5.4 (15.9)	-9.6(18.3)	3.73	3.33	0.262	-0.06	3.86	0.989
Total	147	13.2(1.6)[11.6]	11.8(1.5)[11.3] *	11.6(1.5)[10.8] *^$%
			-8.6(16.4) ^%	-10.1(19.1) ^%
High FA
AA	119	13.7(1.6)[12.7]	11.8(1.5)[11.4] *	11.5(1.4)[10.8] *^$
			-12.3(16.2)	-14.4(17.3)	ref			ref
AG/GG	27	13.5(1.8)[12.9]	11.6(1.5)[11.4] *	11.5(1.5)[10.7] *
			-11.5(22.7)	-11.9(21.5)	1.30	3.39	0.700	2.72	3.60	0.450
Total	146	13.7(1.6)[12.7]	11.7(1.5)[11.4] *	11.5(1.5)[10.8] *^%
			-12.1(17.5) ^%	-13.9(18.1) ^%

¹Geometric mean (anti-log SD), median in brackets;
²[(Homocysteine after treatment - homocysteine at baseline)/( homocysteine at baseline)]*100, Mean(SD);
³Regression model was adjusted for age, sex, BMI, baseline SBP, DBP, creatinine, TG, HDL, TC, FPG, MTHFR C677T polymorphism and study centers;
*Significantly different from baseline, P < 0.05; ^$Significantly different from week 4, P < 0.05;
^%Significantly different from control group, P < 0.05.

ISSN: 1475-2891