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Table 3 Response of plasma Homocysteine to different doses and duration of folic acid supplementation by MTR A2756G genotypes

From: MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults

  N Homocysteine, μmol/L1
Percent relative change of homocysteine2
Difference in change of Homocysteine at 4 weeks by genotypes3 Difference in change of Homocysteine at 8 weeks by genotypes3
   baseline 4 weeks 8 weeks β SE P β SE P
Control           
AA 130 12.8(1.6)[12.0] 12.9(1.6)[11.7] 12.9(1.6)[12.0]       
    1.7(15.1) 2.33(17.7) ref    ref   .
AG/GG 22 12.1(1.5)[11.7] 12.6(6.8)[1.6] 12.6(1.5)[12.2]       
    5.8(15.2) 6.32(20.1) 5.17 3.50 0.139 6.08 4.10 0.138
Total 152 12.7(1.6)[12.0] 12.8(1.6)[11.7] 12.8(1.6)[12.0]       
    2.3(15.1) 2.9(18.0)       
Low FA           
AA 116 12.9(1.6)[11.5] 11.5(1.5)[11.1]* 11.3(1.5)[10.6] *       
    -9.4(16.5) -10.2(19.4) ref    ref   
AG/GG 31 14.1(1.5)[14.5] 13.1(1.5)[12.3] 12.5(1.5)[12.3] *$       
    -5.4 (15.9) -9.6(18.3) 3.73 3.33 0.262 -0.06 3.86 0.989
Total 147 13.2(1.6)[11.6] 11.8(1.5)[11.3] * 11.6(1.5)[10.8] *$%       
    -8.6(16.4) % -10.1(19.1) %       
High FA           
AA 119 13.7(1.6)[12.7] 11.8(1.5)[11.4] * 11.5(1.4)[10.8] *$       
    -12.3(16.2) -14.4(17.3) ref    ref   
AG/GG 27 13.5(1.8)[12.9] 11.6(1.5)[11.4] * 11.5(1.5)[10.7] *       
    -11.5(22.7) -11.9(21.5) 1.30 3.39 0.700 2.72 3.60 0.450
Total 146 13.7(1.6)[12.7] 11.7(1.5)[11.4] * 11.5(1.5)[10.8] *%       
    -12.1(17.5) % -13.9(18.1) %       
  1. 1Geometric mean (anti-log SD), median in brackets;
  2. 2[(Homocysteine after treatment - homocysteine at baseline)/( homocysteine at baseline)]*100, Mean(SD);
  3. 3Regression model was adjusted for age, sex, BMI, baseline SBP, DBP, creatinine, TG, HDL, TC, FPG, MTHFR C677T polymorphism and study centers;
  4. *Significantly different from baseline, P < 0.05; $Significantly different from week 4, P < 0.05;
  5. %Significantly different from control group, P < 0.05.
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