MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults

Table 2 Response of plasma homocysteine to different doses and duration of folic acid supplementation by MTHFR C677T genotypes

	N	Homocysteine, μmol/L¹ Percent relative change of homocysteine²			Difference in change of Homocysteine at 4 weeks by genotypes³			Difference in change of Homocysteine at 8 weeks by genotypes³
		baseline	4 weeks	8 weeks	β	SE	P	β	SE	P
Control
CC	41	11.6(1.4)[11.3]	11.9(1.3)[11.8]	11.8(1.4)[11.3]
			3.35(13.7)	2.2(14.0)	ref			ref		.
CT	73	11.0(1.4)[11.1]	11.2(1.4)[11.3]	11.3(1.4)[11.1]
			2.25(13.2)	3.1(14.0)	-3.69	2.94	0.209	-1.80	3.45	0.601
TT	38	18.1(1.9)[14.7] ^#	18.0(1.9)[15.6] ^#	18.1(1.8)[16.5] ^#
			1.19(19.7)	3.3(27.0)	-4.05	3.33	0.225	-0.52	3.91	0.895
Total	152	12.7(1.6)[12.0]	12.8(1.6)[11.7]	12.8(1.6)[12.0]
			2.3(15.1)	2.9(18.0)
Low FA
CC	34	11.0(1.3)[11.0]	9.9(1.3)[9.4]*	9.8(1.3)[9.5] *
			-8.8(13.0)	-9.9(14.9)	ref			ref
CT	79	12.6(1.5)[11.4]	11.5(1.4)[11.1] *^#	11.2(1.4)[10.7] *^#$
			-7.6(15.4)	-9.7(16.8)	2.14	3.35	0.523	2.52	3.88	0.516
TT	34	17.5(1.8)[17.2] ^#	15.2(1.7)[14.2] *^#	14.8(1.6)[14.2] *^#
			-10.6(21.3)	-11.2(27.1)	-1.16	3.95	0.769	0.06	4.58	0.989
Total	147	13.2(1.6)[11.6]	11.8(1.5)[11.3] *	11.6(1.5)[10.8] *^$%
			-8.6(16.4) ^%	-10.1(19.1) ^%
High FA
CC	39	11.0(1.4)[10.8]	10.2(1.4)[10.1] *	9.7(1.4)[9.8] *^$
			-5.9(14.2)	-10.8(11.1)	ref			ref
CT	69	12.3(1.3)[12.0]	10.8(1.3)[11.0] *	10.7(1.3)[10.5] *
			-11.2(14.5)	-11.2(16.5)	-6.21	3.19	0.052	-0.47	3.39	0.890
TT	38	20.8(1.8)[19.6] ^#	15.8(1.6)[14.2] *^#	15.4(1.6)[14.1] *^#
			-20.3(22.2) ^#	-22.0(23.8) ^#	-15.51	3.72	< 0.001	-11.12	3.95	0.005
Total	146	13.7(1.6)[12.7]	11.7(1.5)[11.4] *	11.5(1.5)[10.8] *^%
			-12.1(17.5) ^%	-13.9(18.1) ^%

¹Geometric mean (anti-log SD), median in brackets;
²[(Homocysteine after treatment - homocysteine at baseline)/(homocysteine at baseline)]*100, Mean(SD);
³Regression model was adjusted for age, sex, BMI, baseline SBP, DBP, creatinine, TG, HDL-C, TC, FPG, folate, folate change, MTR A2756G polymorphism and study centers;
*Significantly different from baseline, P < 0.05; ^$Significantly different from week 4, P < 0.05;
^#Significantly different from the CC genotype, P < 0.05; ^%Significantly different from control group, P < 0.05.

ISSN: 1475-2891