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Table 2 Response of plasma homocysteine to different doses and duration of folic acid supplementation by MTHFR C677T genotypes

From: MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults

  N Homocysteine, μmol/L1
Percent relative change of homocysteine2
Difference in change of Homocysteine at 4 weeks by genotypes3 Difference in change of Homocysteine at 8 weeks by genotypes3
   baseline 4 weeks 8 weeks β SE P β SE P
Control           
CC 41 11.6(1.4)[11.3] 11.9(1.3)[11.8] 11.8(1.4)[11.3]       
    3.35(13.7) 2.2(14.0) ref    ref   .
CT 73 11.0(1.4)[11.1] 11.2(1.4)[11.3] 11.3(1.4)[11.1]       
    2.25(13.2) 3.1(14.0) -3.69 2.94 0.209 -1.80 3.45 0.601
TT 38 18.1(1.9)[14.7] # 18.0(1.9)[15.6] # 18.1(1.8)[16.5] #       
    1.19(19.7) 3.3(27.0) -4.05 3.33 0.225 -0.52 3.91 0.895
Total 152 12.7(1.6)[12.0] 12.8(1.6)[11.7] 12.8(1.6)[12.0]       
    2.3(15.1) 2.9(18.0)       
Low FA           
CC 34 11.0(1.3)[11.0] 9.9(1.3)[9.4]* 9.8(1.3)[9.5] *       
    -8.8(13.0) -9.9(14.9) ref    ref   
CT 79 12.6(1.5)[11.4] 11.5(1.4)[11.1] *# 11.2(1.4)[10.7] *#$       
    -7.6(15.4) -9.7(16.8) 2.14 3.35 0.523 2.52 3.88 0.516
TT 34 17.5(1.8)[17.2] # 15.2(1.7)[14.2] *# 14.8(1.6)[14.2] *#       
    -10.6(21.3) -11.2(27.1) -1.16 3.95 0.769 0.06 4.58 0.989
Total 147 13.2(1.6)[11.6] 11.8(1.5)[11.3] * 11.6(1.5)[10.8] *$%       
    -8.6(16.4) % -10.1(19.1) %       
High FA           
CC 39 11.0(1.4)[10.8] 10.2(1.4)[10.1] * 9.7(1.4)[9.8] *$       
    -5.9(14.2) -10.8(11.1) ref    ref   
CT 69 12.3(1.3)[12.0] 10.8(1.3)[11.0] * 10.7(1.3)[10.5] *       
    -11.2(14.5) -11.2(16.5) -6.21 3.19 0.052 -0.47 3.39 0.890
TT 38 20.8(1.8)[19.6] # 15.8(1.6)[14.2] *# 15.4(1.6)[14.1] *#       
    -20.3(22.2) # -22.0(23.8) # -15.51 3.72 < 0.001 -11.12 3.95 0.005
Total 146 13.7(1.6)[12.7] 11.7(1.5)[11.4] * 11.5(1.5)[10.8] *%       
    -12.1(17.5) % -13.9(18.1) %       
  1. 1Geometric mean (anti-log SD), median in brackets;
  2. 2[(Homocysteine after treatment - homocysteine at baseline)/(homocysteine at baseline)]*100, Mean(SD);
  3. 3Regression model was adjusted for age, sex, BMI, baseline SBP, DBP, creatinine, TG, HDL-C, TC, FPG, folate, folate change, MTR A2756G polymorphism and study centers;
  4. *Significantly different from baseline, P < 0.05; $Significantly different from week 4, P < 0.05;
  5. #Significantly different from the CC genotype, P < 0.05; %Significantly different from control group, P < 0.05.