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Table 1 Baseline characteristics of participants by MTHFR C677T or MTR A2756G polymorphism1

From: MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults

   MTHFR C677T MTR A2756G
  All CC CT TT P AA AG/GG P
N 445 114 221 110   365 80  
Sex(Male), no.(%) 191(42.9) 51(44.7) 91(41.2) 49(44.5) 0.761 155(42.5) 36(45.0) 0.678
Age, yrs 57.0(9.8) 57.0(9.5) 56.4(9.6) 58.2(10.4) 0.284 57.0(9.8) 57.0(9.9) 0.971
BMI, kg/m2 25.7(3.5) 25.5(3.9) 25.8(3.3) 25.7(3.3) 0.758 25.8(3.5) 25.2(3.5) 0.137
SBP, mmHg 154.0(11.2) 154.0(11.5) 153.8(11.4) 154.5(10.5) 0.863 153.8(11.2) 155.1(11.2) 0.324
DBP, mmHg 93.0(8.3) 92.4(8.5) 93.4(7.8) 92.8(9.0) 0.530 93.3(8.0) 91.4(9.4) 0.052
FPG, mmol/L 5.5(1.3) 5.5(1.5) 5.4(1.2) 5.7(1.2) 0.312 5.5(1.3) 5.5(1.2) 0.865
TC, mmol/L 5.0(1.1) 5.0(1.4) 4.9(1.0) 5.1(1.0) 0.555 5.0(1.1) 4.9(1.1) 0.259
HDL-C, mmol/L 1.3(0.4) 1.3(0.4) 1.3(0.4) 1.3(0.4) 0.479 1.3(0.4) 1.3(0.3) 0.542
TG, mmol/L 1.7(1.2) 1.7(1.0) 1.8(1.2) 1.7(1.5) 0.970 1.8(1.3) 1.6(0.8) 0.252
Creatinine, μmol/L 69.5(17.5) 68.0(17.5) 69.2(17.3) 71.9(17.9) 0.233 69.2(17.9) 71.3(15.6) 0.334
Folate, nmol/L2 12.6(1.5)[12.3] 13.7(1.4)[13.4] 13.0(1.5)[12.6] 11.0(1.4)[10.8] * < 0.001 12.8(1.5)[12.5] 11.9(1.5)[11.6] 0.107
Homocysteine, μmol/L2 13.2(1.6)[12.1] 11.2(1.4)[11.1] 12.0(1.4)[11.5] 18.8 (1.8)[17.5] * < 0.001 13.1(1.6)[12.1] 13.3(1.6)[12.6] 0.794
  1. BMI = body mass index, SBP = systolic blood pressure, DBP = diastolic blood pressure, FPG = fasting plasma glucose,
  2. TC = total cholesterol, HDL-C = high-density lipoprotein cholesterol, TG = triglyceride;
  3. 1Means (SD); 2geometric mean (anti-log SD), median in brackets; * Significantly different from the CT or CC genotype, P < 0.001.
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