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Table 5 Serum calcium and urinary calcium:creatinine following single-dose vitamin D3 (70,000 IU) in non-pregnant participants

From: Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women

   Total serum calcium conc. (mmol/L) Albumin-adjusted serum calcium concentration (mmol/L) Urine calcium:creatinine ratio (mmol/mmol)
Follow-up time Na Mean (SD) Mean (SD) Range # > 2.60 Na Meanb Median (IQR) Range # > 1.0
0 days 34 2.45 (0.08) 2.37 (0.08) 2.22 to 2.5 0 34 0.21 0.19 (0.22) 0.04 to 1.55 1
2 days 18 2.44 (0.07) 2.36 (0.06) 2.2 to 2.44 0
4 days 16 2.48 (0.06) 2.42 (0.07) c 2.3 to 2.6 0
2nd to 4th week (days 7 to 27) 34 2.44 (0.09) 2.37 (0.08) 2.17 to 2.54 0 47 0.34 d 0.36 (0.23) 0.09 to 1.49 3
5th to 8th week (days 28 to 55) 27 2.44 (0.08) 2.38 (0.06) 2.25 to 2.52 0 53 0.28 0.35 (0.37) 0.01 to 1.12 2
9th to 11th week (days 56 to 76) 18 2.38 (0.09) e 2.33 (0.08) 2.11 to 2.42 0 37 0.24 0.25 (0.26) 0.01 to 0.88 0
Total 147 2.44 (0.09) 2.37 (0.08) 2.11 to 2.6 0 172 0.26 0.3 (0.3) 0.01 to 1.55 6
  1. a. Number of specimens (there may have been multiple specimens for a single participant during a given follow-up period).
  2. b. Geometric means.
  3. c. Mean at day 4 was higher than baseline (+0.05; 95% CI, 0.03 to 0.07) and this remained statistically significant after correction for multiples testing.
  4. d. Means at days 7 and 14 were significantly higher than baseline, after correction for multiple testing.
  5. e. Mean at day 70 was significantly lower than baseline, after correction for multiple testing.