Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women

Nutrition Journal

Table 5 Serum calcium and urinary calcium:creatinine following single-dose vitamin D3 (70,000 IU) in non-pregnant participants

		Total serum calcium conc. (mmol/L)	Albumin-adjusted serum calcium concentration (mmol/L)			Urine calcium:creatinine ratio (mmol/mmol)
Follow-up time	N^a	Mean (SD)	Mean (SD)	Range	# > 2.60	N^a	Mean^b	Median (IQR)	Range	# > 1.0
0 days	34	2.45 (0.08)	2.37 (0.08)	2.22 to 2.5	0	34	0.21	0.19 (0.22)	0.04 to 1.55	1
2 days	18	2.44 (0.07)	2.36 (0.06)	2.2 to 2.44	0	–	–	–	–	–
4 days	16	2.48 (0.06)	2.42 (0.07) ^c	2.3 to 2.6	0	–	–	–	–	–
2nd to 4th week (days 7 to 27)	34	2.44 (0.09)	2.37 (0.08)	2.17 to 2.54	0	47	0.34 ^d	0.36 (0.23)	0.09 to 1.49	3
5th to 8th week (days 28 to 55)	27	2.44 (0.08)	2.38 (0.06)	2.25 to 2.52	0	53	0.28	0.35 (0.37)	0.01 to 1.12	2
9th to 11th week (days 56 to 76)	18	2.38 (0.09) ^e	2.33 (0.08)	2.11 to 2.42	0	37	0.24	0.25 (0.26)	0.01 to 0.88	0
Total	147	2.44 (0.09)	2.37 (0.08)	2.11 to 2.6	0	172	0.26	0.3 (0.3)	0.01 to 1.55	6

^a. Number of specimens (there may have been multiple specimens for a single participant during a given follow-up period).
^b. Geometric means.
^c. Mean at day 4 was higher than baseline (+0.05; 95% CI, 0.03 to 0.07) and this remained statistically significant after correction for multiples testing.
^d. Means at days 7 and 14 were significantly higher than baseline, after correction for multiple testing.
^e. Mean at day 70 was significantly lower than baseline, after correction for multiple testing.

ISSN: 1475-2891