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Table 7 Multi regression analysis in which MTHFR polymorphism, Homocysteine level, HCV genotype and lipid profile as a independent variables for steatosis

From: Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and high plasma homocysteine in chronic hepatitis C (CHC) infected patients from the Northeast of Brazil

Variables

OR (CI 95%)

p*

OR adjusted

p

OR adjusted

p

Gender: F/M

1.1 (0.6-2.0)

0.88

1.1(0.5-2.3)

0.90

1.1 (0.5-2.3)

0.87

HOMA ≥ 2.5

1.5 (0.7-3.2)

0.35

1.3 (0.6-2.9)

0.40

1.4 (0.7-3.1)

0.35

LDL cholesterol ≥ 130

0.5 (0.2-1.6)

0.35

0.6 (0.2-1.9)

0.35

- (**)

-

HDL cholesterol ≤ 40

1.1 (0.5-2.4)

0.84

0.9 (0.4-2.1)

0.82

1.0 (0.4-2.2)

0.93

Total Cholesterol ≥ 200

0.8 (0.2-2.9)

0.75

- (**)

-

0.9 (0.2-3.6)

0.96

Triglyceride ≥ 150

0.6 (0.2-1.8)

0.38

0.6 (0.2-1.9)

0.40

0.6 (0.2-1.9)

0.37

TT+CT (MTHFR)

0.8 (0.4-1.5)

0.64

1.0 (0.5-2.1)

0.94

1.0 (0.5-2.1)

0.95

Homocysteine ≥ 9

1.6 (0.8-3.3)

0.18

1.6 (0.7-3.3)

0.24

1.6 (0.7-3.3)

0.25

  1. *Fisher Test ** Collinearity
  2. References values:
  3. Triglyceride < 150 mg/dL, Total Cholesterol < 200 mg/dL, LDL-c < 130 mg/dL, HDL-c > 40 mg/dL, HOMA: < 2.5, Homocysteine < 9.0 ÎĽmol/L
  4. CI: confidence interval