Skip to main content

Table 2 Evaluation of therapeutic effect of milk antibody treatment in 18 patients in test group.

From: Supplemental treatment of rheumatoid arthritis with natural milk antibodies against enteromicrobes and their toxins: results of an open-labelled pilot study

Patient
ID
Eval
Point1)
ACR2)
Criteria
DAS28-ESR Remarks of improvements DRB1-
Allele
    Pre Post Δ EULAR3) GI4) General condition5)   
Responders
3709 8 20 6.01 3.47 2.54 Moderate C (+) Fatigue, Anemia, Weight loss 0101 0405
3188 8 20 6.31 4.82 1.49 Moderate C (+) ADL 0405 0404
4119 6 50 4.61 3.39 1.22 Moderate (/) Range of motion 0901 1406
198 6 <20 8.02 7.13 0.89 No C (+) Fatigue, Anemia 0803 1401
5284 5 <20 4.32 3.07 1.25 Good C (+) Unhealthy feeling 0410 1502
10572 3 <20 6.12 6.08 0.04 No C (+) Appetite, Sleep 1302 1406
1316 3 <20 4.34 4.21 0.13 No C (+) Fatigue ND ND
3240 3 <20 5.29 4.63 0.66 Moderate D (+) Unhealthy feeling 0405 1202
Ave 5.3 ± 2.1   5.63 ± 1.26 4.66 ± 1.43 0.97 ± 0.87   (7/7)    
Pre vs. Post     P < 0.01   P < 0.01    
Partial responders
169 2 <20 5.26 6.22 -0.96 No (/) Fatigue, Intra-articular effusion 0901 -
511 1 <20 8.15 7.85 0.30 No D (+) Range of motion 0405 1101
Ave 1.5 ± 0.7   6.75 ± 2.10 7.04 ± 1.15 -0.33 ± 0.89   (1/1)    
Non-Responders
9291 2 <20 4.70 5.04 -0.34 No C (+) - 0803 1501
3007 1 <20 4.44 5.85 -1.41 No (/) - 1101 1502
2264 1 <20 8.00 7.86 0.14 No C (+) - 0405 -
721 1 <20 6.33 6.29 -0.04 No C (+) - 0405 1501
7785 0 <20 6.22 7.58 -1.36 No C (-) Edema at lower thigh 0901 1501
2110 0 <20 ND ND ND ND C (-) - 0405 1502
8861 0 <20 4.01 5.68 -1.67 No C (-) - 0901 1501
10164 0 <20 4.45 4.94 -0.49 No (/) - 0405 1501
Ave 0.6 ± 0.7   5.45 ± 1.44 6.18 ± 1.15 -0.73 ± 0.74   (3/6)    
Pre vs. Post     NS   NS    
Responder vs. Non-Responder NS P < 0.05       
  1. 1) Number of categories among 8 categories gained more than 20% improvement. 2) American College of Rheumatology, 3) European League Against Rheumatism response criteria using DAS28-ESR. 4) Gastrointestinal disorder, C: Constipation, D: Diarrhea, (+): improved, (-): not improved, (/): no GI disorder. 5) ADL: activities of daily living.
  2. ND: Not determined, NS: Not significant.