Inflammatory mediator response to three high fat meals differing in fat type. Plasma a) C-reactive protein (CRP) increased over time (p < 0.05), b) tumor necrosis factor-α (TNF-α) decreased over time (p < 0.001), c) Soluble vascular cell adhesion molecule-1 (VCAM-1) tended to decrease over time (p < 0.085), and d) Soluble intercellular adhesion molecule-1 (ICAM-1) but remained lower for MFA (p = 0.031) than both O3FA and SFA, and the area under the curve was higher for SFA than MFA (p = 0.051) as assessed by ELISA. Data are presented as Mean ± SEM. O3FA = omega 3 fatty acid enriched meal, SFA = high saturated fat meal, and MFA = high monounsaturated fat meal. * indicates time point difference from baseline (p < 0.05).