The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: A randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults

Table 1 Summary of measures assessed over the study duration.

Outcome measures and covariates	Time points (months)
	~ -3	0	6	12	18
MMSE	x	x			x
Cognitive measures		x	x	x	x
Physical activity, functional capacity, and well-being measures		x	x	x	x
Height		x
Blood pressure, weight		x	x	x	x
Erythrocyte membrane n-3 and n-6 fatty acid status		x	x	x	x
Serum folate and Vitamin B12, and plasma carotenoid levels		x			x
Lipids, glucose, glycated haemoglobin, homocysteine		x			x
Medications, supplement use, adverse events and health changes		x	x	x	x
ApoE genotype		x
Inflammation (CRP), oxidative stress (MDA), and telomere length		x			x
Dietary data - general FFQ		x			x
Dietary data - n-3 consumption FFQ		x	x	x	x
Dietary data - historical seafood consumption FFQ			x

Abbreviations: MMSE = Mini-mental state examination; n-3 = omega-3; n-6 = omega-6; FFQ = food frequency questionnaire; ApoE = Apolipoprotein E.

ISSN: 1475-2891