Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects

Holmer-Jensen, Jens; Karhu, Toni; Mortensen, Lene S; Pedersen, Steen B; Herzig, Karl-Heinz; Hermansen, Kjeld

doi:10.1186/1475-2891-10-115

Table 2 Fasting concentrations and net incremental areas under the curve after 240 min (net iAUC 0-240 min)¹ for inflammatory markers, insulin and triglycerides in 11 (8 women and 3 men) obese non-diabetic subjects in response to the four test-meals

From: Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects

	Cod	Whey	Gluten	Casein
MCP-1
Fasting	22 ± 11	21 ± 7	23 ± 12	21 ± 11
iAUC 0-240 min (pg/ml·240 min)	- 826 ± 1255x	- 77 ± 1092y	-943 ± 925x	-469 ± 757xy
CCL5
Fasting	340 ± 238	490 ± 396	490 ± 321	409 ± 297
iAUC 0-240 min (pg/ml·240 min)	50 764 ± 58 218x	- 18 510 ± 81 999y	11 235 ± 55 558yz	44 488 ± 37 862xz
IL-1ra
Fasting	68 ± 18	79 ± 39	76 ± 34	66 ± 24
iAUC 0-240 min (pg/ml·240 min)	743 ± 2 871	-1 972 ± 4 005	-1 454 ± 5 068	2 173 ± 4 320
PDGF-bb1
Fasting	40 ± 41	161 ± 260	65 ± 78	110 ± 232
iAUC 0-240 min (pg/ml·240 min)	11 837 (6 285 - 20 952)	4 303 (2 102 - 6 995)	6 660 (4851 - 10 742)	8 604 (6348 - 10 435)
IFN-g
Fasting	25 ± 12	28 ± 25	30 ± 21	28 ± 24
iAUC 0-240 min (pg/ml·240 min)	865 ± 1 610	-1 300 ± 3 747	-791 ± 2 622	397 ± 2 614
Adiponectin
Fasting	1.5 ± 0.5	1.5 ± 0.6	1.5 ± 0.6	1.5 ± 0.5
iAUC 0-240 min (μg/ml·240 min)	-7.7 ± 48	-8.5 ± 49	6.3 ± 38	-6.9 ± 36
Eotaxin
Fasting	52 ± 12	53 ± 14	51 ± 14	49 ± 16
iAUC 0-240 min (pg/ml·240 min)	- 45 ± 819	601 ± 2237	- 64 ± 686	983 ± 1039
G-CSF
Fasting	11 ± 3	12 ± 6	11 ± 4	12 ± 7
iAUC 0-240 min (pg/ml·240 min)	23 ± 719	-420 ± 1 242	-114 ± 685	-194 ± 955
IP-10
Fasting	579 ± 166	558 ± 109	588 ± 226	542 ± 142
iAUC 0-240 min (pg/ml·240 min)	-2 343 ± 24 198	-10 371 ± 19 737	-3 403 ± 21 448	-5 159 ± 10 121
MIP-1b
Fasting	45 ± 16	46 ± 16	44 ± 14	43 ± 15
iAUC 0-240 min (pg/ml·240 min)	-908 ± 1 248	-331 ± 1 411	-302 ± 534	-219 ± 428
VEGF
Fasting	7 ± 3	10 ± 6	7 ± 3	8 ± 4
iAUC 0-240 min (pg/ml·240 min)	693 ± 921	270 ± 1 058	233 ± 448	317 ± 419
Insulin
Fasting	65 ± 28	63 ± 33	66 ± 31	62 ± 32
iAUC 0-240 min (pmol/l·240 min)	41 158 ± 11 003x	73 693 ± 28 022y	38 738 ± 10 691x	50 978 ± 21 477x
Triglycerides
Fasting	2.0 ± 1.0	1.8 ± 0.8	1.9 ± 0.7	1.8 ± 0.9
iAUC 0-240 min (mmol/l·240 min)	138 ± 108	122 ± 95	132 ± 95	127 ± 94

¹All values are means ± SDs (normal distributions; mixed-effects model, Tukey's post hoc correction) or medians with interquartile ranges in parentheses (skewed distribution; mixed-effects model on normal distributed log-transformed data, Tukey's post hoc correction). Meals: energy-free soup plus 100 g butter and 45 g carbohydrate consumed with either 45 g cod, 45 g whey isolate, 45 g gluten or 45 g casein. MCP-1: monocyte chemotactic protein-1; CCL5: Chemokine ligand 5; IL-1ra: interleukin 1 receptor-antagonist; PDGF-bb1: platelet derived growth factor BB; IFN-g: interferon-gamma; G-CSF: granulocyte colony-stimulating factor; IP-10: interferon-gamma induced protein 10 kDa; MIP-1b: macrophage inflammatory protein 1b; VEGF: vascular endothelial growth factor. Values in a row with different superscript letters are significantly different, P < 0.05.

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ISSN: 1475-2891

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